A Generic Basis for Some Simple Light-Operated Mechanical Molecular Machines

Lara, David Pérez de; Dryden, David T. F.; Leigh, David A.; Teobaldi, Gilberto; Zerbetto, Francesco

doi:10.1021/ja0484193

Cited by 201 publications

(89 citation statements)

References 9 publications

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“…[10] Some of these molecular mechanical switches have been designed specifically to perform particular functions, such as molecular muscles, [11] molecular elevators [12] and even molecular walkers. [13] However, most current artificial systems controlled by molecular shuttles are operated only as on/off switches and not in an adjustable multilevel mode.…”

Section: Introductionmentioning

confidence: 99%

A Molecular Shuttle for Driving a Multilevel Fluorescence Switch

Zhou

et al. 2007

Chemistry A European J

128

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A [2]rotaxane-based molecular shuttle comprised a macrocycle mechanically interlocked to a chemical "dumbbell" has been prepared in high yields by a thermodynamically controlled, template-induced clipping procedure. This molecular shuttle has two different recognition sites, namely, -NH2 +- and amide, separated by a phenyl unit. The macrocycle exhibits high selectivity for the -NH2+- recognition sites in the protonated form through noncovalent interactions, which include 1) N+-H...O hydrogen bonds; 2) C-H...O interactions between the CH2NH2+CH2 protons on the thread and the oligo(ethylene glycol) unit in the macrocycle; 3) pi...pi stacking interaction between macrocycle and aromatic unit. Upon deprotonation of the [2]rotaxane the macrocycle glides to the amide recognition site due to the hydrogen bonds between the -CONH- group and the oligo(ethylene glycol) unit in the macrocycle. The deprotonation process requires about 10 equivalents of base (iPr2NEt) in polar acetone, while the amount of base is only 1.2 equivalents in apolar tetrachloroethane. Upon addition of Li+, the conformation of the [2]rotaxane was altered as a result of the collective interactions of 1) hydrogen bonds between pyridine nitrogen and amide hydrogen atoms; 2) coordination between the oligo(ethylene glycol) unit, amide oxygen atom and Li+ cation. Then, when Zn2+ ions are added, the macrocycle returns to the deprotonated -NH- recognition site owing to coordination of the macrocycle and -NH- from the axle with the Zn2+ ion. All the above-mentioned movement processes are reversible through the alternate addition of TFA/iPr2NEt, Li/[12]-crown-4 and Zn2+/ethylenediaminetetraacetate (EDTA), by virtue of hydrogen bonding and metal-ion complexation. Significantly, the three independent movement processes are all accompanied by fluorescent responses: 1) complete repression in the protonated form; 2) low-level expression in the deprotonated form; 3) medium-level expression following addition of Li+; 4) high-level expression on complexation with Zn2+.

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Section: Introductionmentioning

confidence: 99%

A Molecular Shuttle for Driving a Multilevel Fluorescence Switch

Zhou

et al. 2007

Chemistry A European J

128

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“…La síntesis de F1F0-ATP utiliza un motor biológico rotacional que se ubica en las membranas mitocondriales, bacterianas y de cloroplastos, que son responsables de la generación de ATP [29]. Los científicos han desarrollado una interesante "caja de nano-herramientas", llena de nano-objetos tales como nanotubos [30], nanoalambres [31], trasladadores moleculares [32], conmutadores moleculares [33] y motores [34], los que fueron diseñados para cumplir funciones muy diversas. En esta sección del curso los alumnos indagarán sobre los principales ejemplares.…”

Section: Dispositivos Nanométricos Y Máquinas Molecularesunclassified

Nanociencia y nanotecnología en carreras de ingeniería

Mendoza

2018

rev.digit.educ.ing

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Resumen-La nanociencia y la nanotecnología son campos interdisciplinarios de la ciencia y la tecnología que han tenido un gran impacto en las últimas décadas. Si bien sus aplicaciones aparecen en todas las ramas de la ingeniería, la formación en nanotecnología para ingenieros se suele restringir a cursos de posgrado. Por ello resulta necesario introducir la temática en etapas de formación más tempranas. En consecuencia, este trabajo presenta un diseño curricular para la enseñanza de nanociencia y nanotecnología en carreras de ingeniería, a nivel de grado. La propuesta se puede incorporar en carreras de ingeniería diversas y fue recientemente implementada en el programa de ingeniería electromecánica de la Universidad Tecnológica Nacional.Palabras Clave-nanociencia; nanotecnología; ingeniería; diseño curricular.Recibido: 10 de octubre de 2017. Revisado: 12 de diciembre de 2017. Aceptado: 5 de febrero de 2018. Nanoscience and nanotechnology for engineering educationAbstract-Nanoscience and nanotechnology are interdisciplinary fields of science and technology that have had great impact in recent decades. While applications appear in all branches of engineering, education in nanotechnology for engineers is usually restricted to postgraduate courses. Therefore, it is necessary to introduce the subject at earlier stages of formation. Thus, this paper presents a curricular design for introducing nanoscience and nanotechnology to undergraduate engineers. The proposal can be incorporated into various engineering careers and was recently implemented in the program of Electromechanical Engineering of the Universidad Tecnológica Nacional.

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“…Pérez et al [59] designed a "bead on a string" rotaxane consisting of 18 and 19. The bead 18 sits on the trans-fumaric diamide station due to a hydrogen-bond array of high strength in dichloromethane solution.…”

Section: Photon Inputsmentioning

confidence: 99%

Molecular Logic Gates and Luminescent Sensors Based on Photoinduced Electron Transfer

Silva

Uchiyama

2010

Luminescence Applied in Sensor Science

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The competition between Photoinduced electron transfer (PET) and other de-excitation pathways such as fluorescence and phosphorescence can be controlled within designed molecular structures. Depending on the particular design, the resulting optical output is thus a function of various inputs such as ion concentration and excitation light dose. Once digitized into binary code, these input-output patterns can be interpreted according to Boolean logic. The single-input logic types of YES and NOT cover simple sensors and the double- (or higher-) input logic types represent other gates such as AND and OR. The logic-based arithmetic processors such as half-adders and half-subtractors are also featured. Naturally, a principal application of the more complex gates is in multi-sensing contexts.

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A Generic Basis for Some Simple Light-Operated Mechanical Molecular Machines

Cited by 201 publications

References 9 publications

A Molecular Shuttle for Driving a Multilevel Fluorescence Switch

A Molecular Shuttle for Driving a Multilevel Fluorescence Switch

Nanociencia y nanotecnología en carreras de ingeniería

Molecular Logic Gates and Luminescent Sensors Based on Photoinduced Electron Transfer

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