For soft soils, the creep settlement plays an important role in the full life-cycle performance of infrastructures, which is a serious concern for engineers and researchers. Columns, e.g. deep cement mixed (DCM) soil columns, are commonly adopted to treat soft grounds in order to reduce the full-life settlement of the infrastructures. However, the creep behavior of soft grounds treated by DCM soil columns is often neglected, inducing underestimated total settlements or unexpected differential settlements. In this study, a new calculation method is developed for the life-cycle settlement of column-improved soft grounds by considering the creep of soft soils and load transfer between the columns and surrounding soils. A physical model test with double-layer soils improved by DCM soil columns was designed and performed to demonstrate the feasibility of the calculation method. It is found that the settlements calculated by the proposed method show good agreement with the measured data in the physical model. A parametric study was conducted, revealing that the calculated settlement of the double-layer soil improved by DCM columns can be largely influenced by the stress concentration ratio, the permeability of the DCM columns, and the area replacement ratio. Finally, the proposed method was applied to calculate the settlement in a real project.