A generalizable one health framework for the control of zoonotic diseases

Ghai, Ria R.; Wallace, Ryan M.; Kile, James C.; Shoemaker, Trevor; Vieira, Antonio; Negrón, María; Shadomy, Sean V.; Sinclair, Julie R.; Goryoka, Grace W; Salyer, Stephanie J.; Behravesh, Casey Barton

doi:10.1038/s41598-022-12619-1

Cited by 62 publications

(43 citation statements)

References 61 publications

(57 reference statements)

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“…The high prevalence of Toxocara larvae in paratenic hosts may lead to spillover from the sylvatic to the synanthropic cycle due to stray and pet dogs feeding on wild rodents 81 . Biomonitoring of pathogen dynamics in their wildlife reservoir is pivotal in understanding their epidemiology and facilitating informed decisions on the control of zoonotic diseases 32 , 82 , 83 . Our study shows that different environments may differ significantly in supporting the local presence of the parasite, and hence sampling design is of critical importance in studies of the regional prevalence of parasites.…”

Section: Discussionmentioning

confidence: 99%

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara spp.

Krupińska

Antolová

Tołkacz

et al. 2023

Sci Rep

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Small mammals are suspected of contributing to the dissemination of Toxocara canis and helping with the parasite survival during periods when there is a temporary absence of suitable definitive hosts. While the primary aim of the current study was the assessment of seroprevalence of Toxocara spp. infections in wild rodents in Poland, we also explored the role of intrinsic (sex, age) and extrinsic factors (study site) influencing dynamics of this infection to ascertain whether grassland versus forest rodents play a greater role as indicators of environmental contamination with T. canis. We trapped 577 rodents belonging to four species (Myodes glareolus, Microtus arvalis, Microtus agrestis, Alexandromys oeconomus) in north-eastern Poland. Blood was collected during the parasitological examination, and serum was frozen at − 80 °C until further analyses. A bespoke enzyme-linked immunosorbent assay was used to detect antibodies against Toxocara spp. We found Toxocara spp. antibodies in the sera of all four rodent species with an overall seroprevalence of 2.8% [1.9–4.1%]. There was a significant difference in seroprevalence between vole species, with the grassland species (M. arvalis, M. agrestis and A. oeconomus) showing a 16-fold higher seroprevalence (15.7% [8.7–25.9%]) than the forest-dwelling M. glareolus (0.98% [0.5–1.8%]). We hypothesise that the seroprevalence of Toxocara spp. differs between forest and grassland rodents because of the higher contamination of grasslands by domestic dogs and wild canids. Our results underline the need for wide biomonitoring of both types of ecosystems to assess the role of rodents as indicators of environmental contamination with zoonotic pathogens.

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Section: Discussionmentioning

confidence: 99%

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara spp.

Krupińska

Antolová

Tołkacz

et al. 2023

Sci Rep

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“…The high prevalence of Toxocara larvae in paratenic hosts may lead to spillover from the sylvatic to the synanthropic cycle due to stray and pet dogs feeding on wild rodents [76]. Biomonitoring of pathogen dynamics in their wildlife reservoir is pivotal in understanding their epidemiology and facilitating informed decisions on the control of zoonotic diseases [32,77,78]. Our study shows that different environments may differ signi cantly in supporting the local presence of the parasite, and hence sampling design is of critical importance in studies of the regional prevalence of parasites.…”

Section: Discussionmentioning

confidence: 99%

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara canis

Krupińska

Antonová

Tołkacz

et al. 2022

Preprint

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Small mammals are suspected of contributing to the dissemination of Toxocara canis and helping with the parasite's survival during periods when there is a temporary absence of suitable definitive hosts. While the primary aim of the current study was the assessment of seroprevalence of Toxocara spp. infections in wild rodents in Poland, we also explored the role of intrinsic (sex, age) and extrinsic factors (study site, year of study) influencing dynamics of this infection to ascertain whether grassland versus forest rodents play a greater role as indicators of environmental contamination with T. canis. We trapped 577 rodents belonging to four species (Myodes glareolus, Microtus arvalis, Microtus agrestis, Alexandromys oeconomus) in north-eastern Poland. Blood was collected during the parasitological examination, and serum was frozen at -80°C until further analyses. A bespoke enzyme-linked immunosorbent assay was used to detect antibodies against T. canis. We found T. canis antibodies in the sera of all four rodent species with an overall seroprevalence of 2.8% [1.9-4.1]. There was a significant difference in seroprevalence between vole species, with the grassland species (M. arvalis, M. agrestis, and A. oeconomus) showing a 16-fold higher seroprevalence (15.7% [8.7-25.9]) than the forest-dwelling, M. glareolus (0.98% [0.5-1.8]). We hypothesise that the seroprevalence of T. canis differs between forest and grassland rodents because of the higher contamination of grasslands by domestic dogs and wild canids. Our results underline the need for wide biomonitoring of both types of ecosystems to assess the role of rodents as indicators of environmental contamination with zoonotic pathogens.

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“…This system-based One Health approach ( One Health approach in the prevention of zoonotic diseases [43].…”

Section: One Health Systems: Best Examples and Practices Tripartite Z...mentioning

confidence: 99%

One Health Approach for the Control of Zoonotic Diseases

Erkyihun

Alemayehu

2022

Zoonoses

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Zoonoses are infectious diseases that can be transmitted from animals to humans and/or from humans to animals. Approximately 75% of new emerging and re-emerging disease pathogens are zoonotic: 60% spread from domestic and wild animals, and 80% are of concern regarding bioterrorism. For the past 20 years, the world has faced several zoonotic disease outbreaks. Some zoonoses can cause recurring outbreaks, such as Ebola virus disease, salmonellosis, Marburg disease, rabies and anthrax. Still others, such as the novel coronavirus causing COVID-19, have the potential to cause worldwide pandemics. The high risk of emerging and reemerging disease spillover and burden has been increased by extensive interactions among animals, humans and ecosystems. Hence, this complex health threat strongly requires a multi-sectoral collaboration known as the One Health approach. This article discusses recent scientific policies, initiatives, best practices, systems and challenges in One Health. The critical rapid review method was used, with a particular emphasis on available and recent global information. Literature found in Google Scholar and PubMed, and data publicly available on the websites of major global, regional and national organizations were included. The aim of this article is to provide compiled information and increase awareness.

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A generalizable one health framework for the control of zoonotic diseases

Cited by 62 publications

References 61 publications

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara spp.

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara spp.

Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara canis

One Health Approach for the Control of Zoonotic Diseases

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