A General Technique For Inter-study Registration Of Multi-function And Multi-modality Images

Kang, Lin; Huang, Sung‐Cheng; Guerrero, Thomas; Baxter, Lewis R.; Yu, D.C.; Melega, William P.; Barrio, Jon Ander del; Phelps, M.E.

doi:10.1109/nssmic.1993.701819

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…PET coregistration with volumetric MRI was accomplished using a six-parameter rigid-body transformation program and visual evaluation (Lin et al,, 1994) with realignment and partitioning. Four slices with equal intervals were selected, and the brain lobe regions of interest (ROIs) were drawn manually with the contusion areas excluded.…”

Section: Methodsmentioning

confidence: 99%

Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury

Wright

McArthur

Alger

et al. 2013

Brain Imaging and Behavior

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Traumatic brain injury often results in acute metabolic crisis. We recently demonstrated that this is associated with chronic brain atrophy, which is most prominent in the frontal and temporal lobes. Interestingly, the neuropsychological profile of traumatic brain injury is often characterized as ‘frontal-temporal’ in nature, suggesting a possible link between acute metabolic crisis related-brain atrophy and neurocognitive impairment in this population. While focal lesions and diffuse axonal injury have a well-established role in the neuropsychological deficits observed following traumatic brain injury, no studies to date have examined the possible contribution of acute metabolic crisis-related atrophy in the neuropsychological sequelae of traumatic brain injury. In the current study we employed positron emission tomography, magnetic resonance imaging, and neuropsychological assessments to ascertain the relationship between acute metabolic crisis related-brain atrophy and neurocognitive outcome in a sample of 14 right-handed traumatic brain injury survivors. We found that acute metabolic crisis related-atrophy in the frontal and temporal lobes was associated with poorer attention, executive functioning, and psychomotor abilities at 12 months post-injury. Furthermore, participants with gross frontal and/or temporal lobe atrophy exhibited numerous clinically significant neuropsychological deficits in contrast to participants with other patterns of brain atrophy. Our findings suggest that interventions that reduce acute metabolic crisis may lead to improved functional outcomes for traumatic brain injury survivors.

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Section: Methodsmentioning

confidence: 99%

Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury

Wright

McArthur

Alger

et al. 2013

Brain Imaging and Behavior

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show abstract

“…Coregistration of PET to MR images was performed with a 3-dimensional MR-PET image registration program. 36 The MR images were segmented into 4 different tissue types; image values were assigned with a relative proportion of 4:1:0:0.5 for gray matter, white matter, cerebrospinal fluid, and muscle, respectively. Segmented images were then smoothed 3-dimensionally to match the measured spatial resolution of PET data.…”

Section: Pet Data Analysismentioning

confidence: 99%

Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy

Brody

Saxena²,

Stoessel³

et al. 2001

Arch Gen Psychiatry

537

248

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“…MRI-based region of interest analysis involved coregistering each subject's FDG PET scans with his/her MRI scan (47), then outlining regions of interest on horizontal planes of the MRI scan, as previously described (33,34). Cerebrospinal fluid and white matter were excluded from the outlines of all gray matter regions of interest.…”

Section: Image Analysismentioning

confidence: 99%

Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression

Saxena¹,

Brody²,

Ho³

et al. 2003

AJP

193

141

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These findings suggest that, although both OCD and major depressive disorder respond to SRIs, the two syndromes have different neurobiological substrates for response. Elevated activity in the right caudate may be a marker of responsiveness to antiobsessional treatment, while lower right amygdala activity and higher midline prefrontal activity may be required for response of depressive symptoms to treatment.

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A General Technique For Inter-study Registration Of Multi-function And Multi-modality Images

Cited by 4 publications

References 7 publications

Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury

Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury

Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy

Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression

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