A General Synthesis of 3-Indolealkanoic Acids

Fritz, H.

doi:10.1021/jo01040a502

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2001

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Cited by 16 publications

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“…The key step is the reaction of γ-butyrolactone with 5-methoxyindole [8]. This alkylation reaction takes place at the C-3 position selectively.…”

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confidence: 99%

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A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist

Csende¹

2001

Archiv der Pharmazie

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“…The key step is the reaction of γ-butyrolactone with 5-methoxyindole [8]. This alkylation reaction takes place at the C-3 position selectively.…”

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confidence: 99%

“…These reasons prompted us to search for an alternative method in which the starting material is the commercially available 5-methoxyindole and building of the butyric acid side chain is simpler. The key step is the reaction of γ-butyrolactone with 5-methoxyindole [8]. This alkylation reaction takes place at the C-3 position selectively.…”

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confidence: 99%

A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist

Csende¹

2001

Archiv der Pharmazie

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Properties and Reactions of Indoles, Isoindoles, and Their Hydrogenated Derivatives

Remers¹

1971

Chemistry of Heterocyclic Compounds: A Series of Monographs

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Tetracyclic phenothiazines IV . Synthesis of 1,2,3,4‐Tetrahydro‐azepino [3,2,1‐kl] phenothiazin ‐4‐one

and

Martin

1978

Journal of Heterocyclic Chem

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The synthesis of 1,2,3,4‐tetrahydroazepine[3,2,1‐kl]phenothiazin‐4‐one was accomplished by cyclization of phenothiazine‐10‐butanoic acid using phosphorus pentoxide and absolute ethanol. The title compound represents the first reported example of the azepino[3,2,1‐kl]phenothiazine ring system. A vastly improved malonic ester‐type synthesis of the precursor acid has also been developed.

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A General Synthesis of 3-Indolealkanoic Acids

Cited by 16 publications

References 2 publications

A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist

A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist

Properties and Reactions of Indoles, Isoindoles, and Their Hydrogenated Derivatives

Tetracyclic phenothiazines IV . Synthesis of 1,2,3,4‐Tetrahydro‐azepino [3,2,1‐kl] phenothiazin ‐4‐one

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A General Synthesis of 3-Indolealkanoic Acids

Cited by 16 publications

References 2 publications

A Simple Procedure for Synthesis of Roxindole, a Dopamine D 2 ‐Receptor Agonist

A Simple Procedure for Synthesis of Roxindole, a Dopamine D 2 ‐Receptor Agonist

Properties and Reactions of Indoles, Isoindoles, and Their Hydrogenated Derivatives

Tetracyclic phenothiazines IV . Synthesis of 1,2,3,4‐Tetrahydro‐azepino [3,2,1‐kl] phenothiazin ‐4‐one

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A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist

A Simple Procedure for Synthesis of Roxindole, a Dopamine D ₂ ‐Receptor Agonist