A general procedure for establishing composite quality evaluation indices based on key quality attributes of traditional Chinese medicine

Jia, Chen; Cheng, Xian‐Long; Li, Linfu; Dai, Shuguang; Wang, Ya-Dan; Li, Minghua; Guo, Xiaohan; Wei, Feng; Ma, Shuang‐Cheng

doi:10.1016/j.jpba.2021.114415

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…The results of the qualitative analysis show that lignans, alkaloids, flavonoids, triterpenoids, and gingerols may be the main bioactive compounds in YWD. Based on the outcomes of the analysis of modern pharmacological studies and literature [16,23,25,38,[44][45][46], we are pleased to find that most of them have anti-inflammatory, anti-bacterial, antioxidant, relieving the pain, and regulation of gastrointestinal biological activities, and many studies have reported that they are closely related to the treatment of gastric-related diseases. Among the 11 individual herbs and relevant prescriptions, the most valuable quantitative YWD sample compounds could be screened out as the quality markers accepted in the Chinese Pharmacopoeia and employed for further quality control, such as honokiol and magnolol for MOC, hesperidin for CER, 6-gingerol for ZRR and glycyrrhizic acid for GRR, etc.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive characterization and identification of chemical constituents in Yangwei decoction using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Fan

Tian

et al. 2022

J of Separation Science

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Yangwei decoction, a classical traditional Chinese medicine prescription, has been widely used to treat exogenous cold and internal injury with damp stagnation for many centuries. However, its systematic chemical profiling remains ambiguous, which has hampered the interpretation of pharmacology and the mechanism of its formula. In the present study, ultra‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry method was successfully established for the first time to separate and identify the complicated components of Yangwei decoction. The accurate mass data of the protonated molecules, deprotonated molecules, and fragment ions were detected in positive and negative ion modes. A total of 226 compounds in Yangwei decoction were tentatively identified and unambiguously characterized by comparing their retention times and mass spectrometry data with those of reference standards and literature, including 24 lignans, 18 alkaloids, 9 phenylpropanoid glycosides, 76 flavonoids, 59 triterpenoids, 17 organic acids, 7 gingerols, 8 lactones, and 8 other compounds. The present study provides a novel method of constituents characterization for well‐known Chinese medicine prescriptions. The study aims to lay a robust foundation for future research, providing the holistic quality control and pharmacology of Yangwei decoction.

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Section: Discussionmentioning

confidence: 99%

Comprehensive characterization and identification of chemical constituents in Yangwei decoction using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Fan

Tian

et al. 2022

J of Separation Science

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“…The quality marker (Q‐marker) is a new concept proposed by Liu et al for the quality control of traditional Chinese medicines (TCM) (Liu et al, 2016). Owing to its core elements of being effect‐related, specific, transitive, measurable and relevant to TCM theory (Chen et al, 2021; Lu, Jin, et al, 2022; Lu, Li, et al, 2022), the Q‐marker has attracted great attention, and has been implemented with remarkable success in recent years, helping to break through the bottle‐neck of current quality control of TCM (Ren et al, 2020; Yang et al, 2017; Zhang et al, 2018). The quality control strategy for TCM based on the Q‐marker may also provide examples for the quality control of botanicals, such as ethnic medicines.…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative method for quality control of Itea ilicifolia based on antioxidant Q‐markers

Feng

Zhang

Yang

et al. 2023

Biomedical Chromatography

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Itea ilicifolia Oliv is a folk medicine with antioxidant potential. In this study, the fingerprints of 14 batches of I. ilicifolia were established by HPLC with 17 common peaks.The similarities evaluated by Similarity Evaluation System for Chromatographic Fingerprint of Chinese Materia (version 2012) were >0.89. Ten compounds were identified with definite structures by comparing the retention time and characteristic UV spectral pattern with those of reference substances. The antioxidant capacities of 14 batches of I. ilicifolia were evaluated based on O 2 ÁÀ , DPPH and ABTS Á+ radical scavenging assays in combination with ferric reducing antioxidant power assay. Via multivariate statistical analyses of gray relation analysis, bivariate correlation analysis and partial least squares regression analysis, a study on the spectrum-effect relationship was then performed to screen eight peaks as the antioxidant Q-markers of I. ilicifolia. The contents of representative antioxidant Q-markers (isoorientin, orientin, vitexin, isovitexin and iteafuranal A) in samples were accurately determined to be 0.

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“…The quality control level of TCM has been significantly improved. The quality control of TCM has always been a hot and difficult problem restricting the modernization of TCM [3,4]. With the progress of analysis technology, it is not difficult to determine the authenticity of TCM.…”

Section: Introductionmentioning

confidence: 99%

Quality grade evaluation of Nvjin Pills based on traditional Chinese medicine reference drug and network pharmacology of target‐focused compounds

Lin,

Liu,

Zhang

et al. 2023

J of Separation Science

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To improve the effectiveness of marketed drugs related to active ingredients, it is necessary to designate a more unified quality evaluation standard. Taking Nvjin Pills as an example, this study reported the development of a novel principle of analysis in traditional Chinese medicine. The core of the experiment is to prepare three batches of traditional Chinese medicine reference drugs by high‐quality Chinese materia medica. The active ingredients identified in the herbal formula including glycyrrhizic acid, cinnamaldehyde, paeonol, baicalin, hesperidin, paeoniflorin, and ferulic acid were analyzed in traditional Chinese medicine reference drugs by the high‐performance liquid chromatography method combined with wavelength switching. The simple prediction results of network pharmacological analysis verified the feasibility and reliability of the established quantitative analysis method for seven target‐focused compounds in Nvjin Pills, which were recommended as candidate indicators for quality evaluation ultimately. Using the seven target‐focused compounds as the scientific ruler, quality grade specifications of Nvjin Pills were proposed by comprehensive analysis. Accordingly, 16, 47, and 13 batches of samples were primarily graded as first grade, second grade, and unqualified grade, respectively. This study will provide a chemical basis for quality control of Nvjin Pills, which is necessary for the production process of pharmaceutical development.

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A general procedure for establishing composite quality evaluation indices based on key quality attributes of traditional Chinese medicine

Cited by 11 publications

References 25 publications

Comprehensive characterization and identification of chemical constituents in Yangwei decoction using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Comprehensive characterization and identification of chemical constituents in Yangwei decoction using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Qualitative and quantitative method for quality control of Itea ilicifolia based on antioxidant Q‐markers

Quality grade evaluation of Nvjin Pills based on traditional Chinese medicine reference drug and network pharmacology of target‐focused compounds

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