A General Mechanism for the General Stress Response in Bacteria
Rishika Baral,
Kristin Ho,
Ramasamy P Kumar
et al.
Abstract:The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. The serine/threonine phosphatase RsbU initiates the General Stress Response in
B. subtilis
upon binding a partner protein (RsbT) that is released from sequestration by environmental stresses. We report that RsbT activates RsbU by inducing otherwise flexible linkers of RsbU to form a short coiled-coil that dimerizes and activates the… Show more
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