A General, Effcient and Green Procedure for Synthesis of Dihydropyrimidine‐5‐carboxamides in Low Melting Betaine Hydrochloride/Urea Mixture

Liu, Peng; Hao, Jian-Wu; Zhang, Zhan‐Hui

doi:10.1002/cjoc.201500862

Cited by 22 publications

(4 citation statements)

References 54 publications

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“…This offers a possible explanation for the increase of reaction rate observed for such heterocyclodehydration processes in DES media compared to the longer reaction times needed in VOCs, instead. The role of a DES as a catalytic active species has also been suggested for other reactions [41,43,44,45,46,47,48,49]. A plausible and simple mechanism of formation of 2-AIs 3 from α-chloroketones 1 and guanidines 2 is depicted in Scheme 1.…”

Section: Resultsmentioning

confidence: 85%

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

et al. 2016

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Abstract:A high-yield one-pot two-step synthesis of 2-aminoimidazoles (2-AI), exploiting an under-air heterocyclodehydration process between α-chloroketones and guanidine derivatives, and using deep eutectic solvents (DESs) as nonconventional, "green" and "innocent" reaction media, has been accomplished successfully. The combination of either glycerol or urea with choline chloride (ChCl) proved to be effective for decreasing the reaction time to about 4-6 h in contrast to the 10-12 h usually required for the same reaction run in toxic and volatile organic solvents and under an argon atmosphere. In addition, the use of the ChCl-urea as a DES also enables the direct isolation of triaryl-substituted 2-AI derivatives by means of a simple work-up procedure consisting in filtration and crystallization, and allows the recycle of the DES mixture. A plausible mechanism highlighting the potential role played by hydrogen bonding catalysis has also been illustrated.

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Section: Resultsmentioning

confidence: 85%

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

et al. 2016

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“…In contrast to conventional ILs, DES are biodegradable, safe, non‐toxic and inexpensiv. Choline based ionic liquids play a crucial role in organic synthesis . The advantages of present methods over previously reported methods includes‐i)employs reusable catalytic system; ii) metal and ligand free synthesis avoiding use of aprotic solvents; iii) fast reaction with excellent yields under mild conditions.…”

Section: Resultsmentioning

confidence: 99%

Deep Eutectic Solvent: An Efficient Catalyst for C-O Coupling Reactions.

Pant

Shankarling

2017

ChemistrySelect

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An efficient and facile route has been developed by using greener and reusable deep eutectic solvent (DES) for the synthesis of O-arylated ethers. This process involves nucleophilic aromatic substitution (S N Ar) of various strongly electrondeficient aryl/alkyl halides and phenols with different substituents resulting in good to excellent yields of products (80-96 %). A significant enhancement in the yield as well as rate of the reaction is observed with increase in presence of electron-withdrawing functionality attached to aryl halide moiety. Simplicity of this catalytic system, cheap cost and easy product isolation procedure makes this protocol economically viable and comparable to metal/ligand catalysed reactions utilizing aprotic solvents. Moreover, the other significant advantages of this method includes mild reaction conditions, short reaction times, easy work up procedure and recyclability of the catalyst up to four runs without remarkable loss in activity.

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“…Therefore, replacement of harmful organic solvents with an eco-friendly medium is one of the major focal points of green chemistry. [3][4][5][6][7][8][9][10] Polyethylene glycol (PEG) and modied polyethylene glycol derivatives have become more popular alternate reaction media, due to their interesting properties like non-toxicity, bio-compatibility, and bio-degradability. Moreover, PEG is considered as a natural, inexpensive, safe, recyclable, degradable, non-ammable, facile, environmentally benign and abundantly available green solvent.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature

Hasaninejad

Beyrati

2018

RSC Adv.

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A General, Effcient and Green Procedure for Synthesis of Dihydropyrimidine‐5‐carboxamides in Low Melting Betaine Hydrochloride/Urea Mixture

Cited by 22 publications

References 54 publications

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

Deep Eutectic Solvent: An Efficient Catalyst for C-O Coupling Reactions.

Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature

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