A general and selective Ni-catalysed reductive amination using hydrazine hydrate as facile hydrogen and nitrogen sources

Abstract

Exploring synthetic methods and catalysts that are easy to handle, highly active, and low-cost for producing industrially important chemicals is a long-term goal in both science and industry. Herein, we...

Nanoarchitectonics of Non-Noble-Metal-Based Heterogeneous Catalysts for Transfer Hydrogenation Reactions: Detailed Insights on Different Hydrogen Sources

“…However, due to several difficulties associated with the use of NH 3 and H 2 , N 2 H 4 ·H 2 O was used as an efficient alternative for the reductive amination of carbonyl with H 2 O as the only byproduct. Primary amines formed from the reductive amination reaction of carbonyl are crucial for their usage in medicines, surfactants, agrochemicals, dyes, and functional materials . In this context, in 2023, Zhu et al developed a Ni-based catalyst supported on alumina (Ni/meso-Al 2 O 3 ) for the reductive amination of 4-methoxybenzyl aldehyde, using N 2 H 4 ·H 2 O as the H 2 and N 2 source, and t -BuOH as a base under a N 2 atmosphere at 100 °C for 12 h with 61%–99% yield.…”

“…Primary amines formed from the reductive amination reaction of carbonyl are crucial for their usage in medicines, surfactants, agrochemicals, dyes, and functional materials. 142 In this context, in 2023, Zhu et al 142 developed a Ni-based catalyst supported on alumina (Ni/ meso-Al 2 O 3 ) for the reductive amination of 4-methoxybenzyl aldehyde, using N 2 H 4 •H 2 O as the H 2 and N 2 source, and t-BuOH as a base under a N 2 atmosphere at 100 °C for 12 h with 61%−99% yield. The catalyst was synthesized by using a two-step method, as shown in Figure 20a.…”

“…Schematic illustration for (a) the synthesis of Ni/meso-Al 2 O 3 catalyst and (b) a plausible reaction pathway over Ni/meso-Al 2 O 3 catalyst for the reductive amination reaction using hydrazine hydrate. [Reproduced with permission from ref . Copyright 2023, Royal Society of Chemistry, London.…”