A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

Gubbay, John; Collignon, Jérôme; Koopman, Peter; Capel, Blanche; Economou, Androulla; Münsterberg, Andrea; Vivian, Nigel; Goodfellow, Peter N.; Lovell-Badge, Robin

doi:10.1038/346245a0

Cited by 1,526 publications

(943 citation statements)

References 42 publications

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“…These markers provided an average coverage of 10 cM along each chromosome. In addition, a single non-polymorphic marker for Chr.Y (SRY 23 ) was used to ascertain sex (markers are listed in Table 1). The largest distance separating any two markers or one marker from chromosome end was 18 cM for the proximal portion of Chr.X, and 18.6 cM for the distal portion of Chr.7.…”

Section: Resultsmentioning

confidence: 99%

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

Fortin

et al. 2000

Genes Immun

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Section: Resultsmentioning

confidence: 99%

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

Fortin

et al. 2000

Genes Immun

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“…[38][39][40] The SOX genes are divided into subfamilies primarily based on the amino-acid sequence homology of the HMG domain. 41 SOX10 is thought to have an essential role in differentiation of neural crest into Schwann cells, astrocytes and oligodendrocytes.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma

et al. 2014

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Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant diagnostic challenge given similar histomorphology. The distinction is further complicated by similar immunophenotype and especially by occasional synovial sarcomas that present as intraneural tumors. Although the presence of a t(X;18) rearrangement or expression of TLE1 can help confirm the diagnosis of synovial sarcoma, negative results for these tests are not diagnostic of malignant peripheral nerve sheath tumor. The SOX10 transcription factor, a putative marker of neural crest differentiation, may have diagnostic utility in this differential, but immunohistochemical data are limited. The goal of the present study was to determine the diagnostic utility of SOX10 to discriminate between synovial sarcoma and malignant peripheral nerve sheath tumor. Forty-eight cases of malignant peripheral nerve sheath tumor, all from patients with documented neurofibromatosis, and 97 cases of genetically confirmed synovial sarcoma, including 4 intraneural synovial sarcomas, were immunohistochemically stained for SOX10. The stain was scored for intensity and fraction of cells staining. Thirty-two of 48 malignant peripheral nerve sheath tumors (67%) were SOX10-positive. The majority of malignant peripheral nerve sheath tumors showed Z2 þ staining, but staining did not correlate with grade. By contrast, only 7/97 (7%) synovial sarcomas were SOX10-positive. Only three synovial sarcomas showed Z2 þ staining but, importantly, two of these were intraneural synovial sarcoma. Therefore, SOX10 is a specific (93%), albeit not very sensitive (67%), diagnostic marker to support a diagnosis of malignant peripheral nerve sheath tumor over synovial sarcoma. Furthermore, the stain needs to be interpreted with caution in intraneural tumors in order to avoid a potential diagnostic pitfall. It remains to be determined whether SOX10-positive cells in intraneural synovial sarcoma represent entrapped Schwann cells, synovial sarcoma cells or both.

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“…The Sox gene family was first identified by homology to the HMG box of the sex-determining gene SRY 19 . Sox17-null mouse embryos exhibit a deficiency of definitive endoderm 20 , and overexpression of Sox17 in ES cells results in the establishment of stable endoderm progenitors 21 .…”

Section: Introductionmentioning

confidence: 99%

Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis

Oshima

Oguma

et al. 2009

Gastroenterology

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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

Cited by 1,526 publications

References 42 publications

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma

Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis

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