1990
DOI: 10.1038/346245a0
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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

Abstract: A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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Cited by 1,526 publications
(943 citation statements)
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“…These markers provided an average coverage of 10 cM along each chromosome. In addition, a single non-polymorphic marker for Chr.Y (SRY 23 ) was used to ascertain sex (markers are listed in Table 1). The largest distance separating any two markers or one marker from chromosome end was 18 cM for the proximal portion of Chr.X, and 18.6 cM for the distal portion of Chr.7.…”
Section: Resultsmentioning
confidence: 99%
“…These markers provided an average coverage of 10 cM along each chromosome. In addition, a single non-polymorphic marker for Chr.Y (SRY 23 ) was used to ascertain sex (markers are listed in Table 1). The largest distance separating any two markers or one marker from chromosome end was 18 cM for the proximal portion of Chr.X, and 18.6 cM for the distal portion of Chr.7.…”
Section: Resultsmentioning
confidence: 99%
“…[38][39][40] The SOX genes are divided into subfamilies primarily based on the amino-acid sequence homology of the HMG domain. 41 SOX10 is thought to have an essential role in differentiation of neural crest into Schwann cells, astrocytes and oligodendrocytes.…”
Section: Discussionmentioning
confidence: 99%
“…The Sox gene family was first identified by homology to the HMG box of the sex-determining gene SRY 19 . Sox17-null mouse embryos exhibit a deficiency of definitive endoderm 20 , and overexpression of Sox17 in ES cells results in the establishment of stable endoderm progenitors 21 .…”
Section: Introductionmentioning
confidence: 99%