A Gene Map of the Human Genome

Schuler, Greg; Boguski, Mark S.; Stewart, Elizabeth A.; Stein, Lincoln; Gyapay, Gábor; Rice, Kate; White, Rob; Rodriguez-Tomé, Patricia; Aggarwal, Amita; Bajorek, E.; Bentolila, S; Birren, Bruce; Butler, Adam; Castle, Andrew B.; Chiannilkulchai, Nuchanard; Chu, Angela M.; Clee, C.; Cowles, Sid; Day, Philip J.; Dibling, Thomas; Drouot, Nathalie; Dunham, Ian; Duprat, Simone; East, C.; Edwards, Cathryn; Fan, Jie; Fang, N.; Fizames, Cécile; Garrett, C.; Green, L.; Hadley, David; Harris, Mark; Harrison, Pat Heslop; Brady, Shannon D.; Hicks, Andrew A.; Holloway, Eric; Hui, Lester; Hussain, Syed Yasir; Louis-Dit-Sully, Christine; Ma, Junli; MacGilvery, A.; Mader, Chris; Maratukulam, A.; Matise, Tara C.; McKusick, Kathleen B.; Morissette, Jean; Mungall, Andrew J.; Muselet, Delphine; Nusbaum, H. C.; Page, David C.; Peck, A. I.; Perkins, S.; Piercy, Mark; Qin, Fawn; Quackenbush, John; Ranby, S. A.; Reif, Tim; Rozen, Steve; Sanders, C.; She, Xiaohong; Silva, J.; Slonim, Donna K.; Soderlund, Cari; Sun, Wei; Tabar, P.; Thangarajah, T.; Vega-Czarny, Nathalie; Vollrath, Douglas; Voyticky, S.; Wilmer, T. E.; Wu, Xiaoyun; Adams, Mark D.; Auffray, Charles; Walter, Nicole A.R.; Brandon, Rhonda; Dehejia, Anindya; Goodfellow, Peter N.; Houlgatte, Rémi; Hudson, J. R.; Ide, Susan; Iorio, K. R.; Lee, W. Y.; Seki, Naohiko; Nagase, Takahiro; Ishikawa, Ken-ichi; Nomura, Nobuo; Phillips, Carolyn; Polymeropoulos, Mihael H.; Sandusky, Mina; Schmitt, Karin; Berry, Rebecca; Swanson, Karl; Torres, Rosarelis; Venter, J. Craig; Sikela, James M.; Beckmann, Jacques S.; Weissenbach, Jean; Myers, R; Cox, David; James, M. R.; Bentley, David; Deloukas, Panos; Lander, Eric S.; Hudson, Thomas J.

doi:10.1126/science.274.5287.540

Cited by 842 publications

(575 citation statements)

References 34 publications

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“…We searched the map of expressed human gene tags (Schuler et al, 1996; http://www.ncbi.nlm.nih.gov/cgibin/SCIENCE96/) for transcripts mapping to this chromosomal region in a ®rst bid to identify the tumour suppressor gene.…”

Section: Resultsmentioning

confidence: 99%

“…The expressed sequence tags (ESTs) T57690 and D29206 have been mapped to the genomic intervals between D7S486 and D7S2487 (125 ± 126 cM from 7pter) and D7S523 and D7S486 (123 ± 125 cM from 7pter) respectively, using the Stanford G3 and Genebridge 4 radiation hybrid mapping panels (Schuler et al, 1996). These adjacent genomic intervals comprise approximately 2 Mbp of¯anking DNA.…”

Section: Resultsmentioning

confidence: 99%

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Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

et al. 1999

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

et al. 1999

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“…Both genes encode Gprotein coupled receptors which have wide biological activities (Hsieh et al, 1990;Herzog et al, 1996). HTR2 is mapped centromeric to Rb1 on 13q14.2, while U16 is located in the intron 17 or Rb1 (Hsieh et al, 1990;Herzog et al, 1996;Schuler et al, 1996). In the distal critical region, one TSG candidate may be the DBM gene which has been found to be homozygously deleted in B cell malignancy (Liu et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Identification of two distinct deleted regions on chromosome 13 in prostate cancer

Larsson

Futreal

et al. 1998

Oncogene

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Aberrations of 13q occur frequently in prostate cancer and this chromosome contains two known tumor suppressor genes, BRCA2 and Rb1. This study analysed 13q LOH, DNA ploidy, BRCA2 mutation and pRb expression in prostate cancers. In total, 13q deletions were found in 18 of 36 tumors but did not correlate with histological grade, stage or DNA ploidy. Two smallest regions of overlapping deletions were de®ned: one¯anked by D13S218 and D13S153; the other¯anked by D13S31 and D13S137. BRCA2 was less frequently deleted whereas Rb1 did have a high frequency of deletion. None of the two genes was located in any of these two regions. Furthermore, BRCA2 mutation was not found in the ®ve tumors where deletions had involved the BRCA2 locus. Neither did the Rb1 deletion correlate with absent pRb expression. In addition, tetraploidy was found in 14 out of 25 tumors analysed and correlated with aberrant pRb expression. Our results indicate that 13q deletion is an early non-random event. Tumor suppressor genes other than BRCA2 or Rb1 may be the target of 13q deletions. Aberrant pRb expression may not re¯ect the two-hit Rb1 inactivation but may be involved in the tetraploidization of prostate cancer cells.

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“…The chromosomal location of the gene for MKP5 was determined by the identi®cation of a previously mapped sequence tagged site (STS) within the MKP5 cDNA (STS WI-16074) (Schuler et al, 1996), and localizes to human chromosome 1q32, between the framework markers WI-4922 and WI-6955 (Figure 3). These mapping data can be accessed using the World Wide Web server of the Whitehead Institute (http:// www.genome.wi.mit.edu/cgi-bin/contig/phys_map).…”

Section: Chromosomal Location Of the Mkp5 Genementioning

confidence: 99%

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

Theodosiou

Smith

Gillieron³

et al. 1999

Oncogene

130

105

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Dual-speci®city protein tyrosine phosphatases are a burgeoning family of enzymes, some of which, the MKPs, are implicated in the regulation of mitogenactivated protein (MAP) kinases. MKPs have been shown to reverse the activation of the MAP kinases by hydrolyzing phosphothreonine and phosphotyrosine residues present in the substrates. Here we describe the characterization of a novel member of the MKP family, MKP5. The MKP5 gene, which maps to human chromosome 1q32, is expressed tissue-speci®cally as two transcripts of approximately 3.4 and 2.4 kb in human liver and skeletal muscle. When expressed in mammalian cells, MKP5 blocks the enzymatic activation of MAP kinases with the selectivity p38&JNK/ SAPK44ERK. Immunoprecipitation of endogenous MAP kinases by the catalytically inactive transfected MKP5 demonstrates that it preferentially binds to the p38 and JNK/SAPK kinases. These ®ndings suggest that the selectivity of this phosphatase may be determined at least in part at the level of substrate binding.

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A Gene Map of the Human Genome

Cited by 842 publications

References 34 publications

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

Identification of two distinct deleted regions on chromosome 13 in prostate cancer

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

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