A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana.

Mizoguchi, Tsuyoshi; Irie, Kenji; Hirayama, Takashi; Hayashida, Nobuaki; Yamaguchi-Shinozaki, Kazuko; Matsumoto, Kunihiro; Shinozaki, Kazuo

doi:10.1073/pnas.93.2.765

Cited by 465 publications

(326 citation statements)

References 48 publications

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“…The mkk2 mutant presents a freezing sensitive phenotype with no observable activity neither for MPK4 nor MPK6, suggesting that MKK2 is an upstream activator of MPK4 and MPK6 in cold signaling. This finding is consistent with previous studies showing that cold stress activates MEKK1, MPK3, MPK4 and MPK6 (Mizoguchi et al 1996;Ichimura et al 2000).…”

Section: Mapks and Temperature Stressessupporting

confidence: 94%

“…Table 1 summarizes a list of MAP kinase genes involved in the responses to multiple abiotic stresses in different plant species, based on changes in transcriptional regulation and/or enzymatic activities. Cold, salinity, dehydration Mizoguchi et al (1996), Moustafa et al (2008), Teige et al (2004) AtMPK4 AtMPK20 Table 1, an inferred MAP kinase cascade can be designed (Fig. 1) and tested in future research for the assessment of plant tolerance to abiotic stresses.…”

Section: Mapks and Temperature Stressesmentioning

confidence: 99%

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MAPK cascades and major abiotic stresses

et al. 2014

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Plants have evolved with complex signaling circuits that operate under multiple conditions and govern numerous cellular functions. Stress signaling in plant cells is a sophisticated network composed of interacting proteins organized into tiered cascades where the function of a molecule is dependent on the interaction and the activation of another. In a linear scheme, the receptors of cell surface sense the stimuli and convey stress signals through specific pathways and downstream phosphorylation events controlled by mitogen-activated protein (MAP) kinases and second messengers, leading to appropriate adaptive responses. The specificity of the pathway is guided by scaffolding proteins and docking domains inside the interacting partners with distinctive structures and functions. The flexibility and the fine-tuned organization of the signaling molecules drive the activated MAP kinases into the appropriate location and connection to control and integrate the information flow. Here, we overview recent findings of the involvement of MAP kinases in major abiotic stresses (drought, cold and temperature fluctuations) and we shed light on the complexity and the specificity of MAP kinase signaling modules.

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Section: Mapks and Temperature Stressessupporting

confidence: 94%

Section: Mapks and Temperature Stressesmentioning

confidence: 99%

MAPK cascades and major abiotic stresses

et al. 2014

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“…The relevance of the MAPK signaling pathway for salt tolerance has been well established in Arabidopsis (Mizoguchi et al, 1996;Ichimura et al, 2000;Teige et al, 2004;Nakagami et al, 2005), whereas in rice relatively little is known. A MAPK module typically consists of three protein kinases: MAP3K, MAP2K, and MAPK.…”

Section: Discussionmentioning

confidence: 99%

SALT-RESPONSIVE ERF1 Regulates Reactive Oxygen Species-Dependent Signaling during the Initial Response to Salt Stress in Rice

et al. 2013

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Early detection of salt stress is vital for plant survival and growth. Still, the molecular processes controlling early salt stress perception and signaling are not fully understood. Here, we identified SALT-RESPONSIVE ERF1 (SERF1), a rice (Oryza sativa) transcription factor (TF) gene that shows a root-specific induction upon salt and hydrogen peroxide (H 2 O 2 ) treatment. Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mitogen-activated protein kinase (MAPK) cascade and salt tolerance-mediating TFs. Furthermore, we show that SERF1-dependent genes are H 2 O 2 responsive and demonstrate that SERF1 binds to the promoters of MAPK KINASE KINASE6 (MAP3K6), MAPK5, DEHYDRATION-RESPONSIVE ELEMENT BINDING2A (DREB2A), and ZINC FINGER PROTEIN179 (ZFP179) in vitro and in vivo. SERF1 also directly induces its own gene expression. In addition, SERF1 is a phosphorylation target of MAPK5, resulting in enhanced transcriptional activity of SERF1 toward its direct target genes. In agreement, plants deficient for SERF1 are more sensitive to salt stress compared with the wild type, while constitutive overexpression of SERF1 improves salinity tolerance. We propose that SERF1 amplifies the reactive oxygen species-activated MAPK cascade signal during the initial phase of salt stress and translates the salt-induced signal into an appropriate expressional response resulting in salt tolerance.

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“…MEKK1 was one of the first MAP3Ks to be characterized in Arabidopsis; it is transcriptionally upregulated in response to touch, cold, and salt stress (Mizoguchi et al, 1996;Covic et al, 1999). Studies using the yeast (Saccharomyces cerevisiae) two-hybrid method have indicated that MEKK1 can interact with the MAP2Ks MKK1 and MKK2, which in turn can interact with MPK4 Mizoguchi et al, 1998).…”

mentioning

confidence: 99%

MEKK1 Is Required for flg22-Induced MPK4 Activation in Arabidopsis Plants

et al. 2006

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The Arabidopsis (Arabidopsis thaliana) gene MEKK1 encodes a mitogen-activated protein kinase kinase kinase that has been implicated in the activation of the map kinases MPK3 and MPK6 in response to the flagellin elicitor peptide flg22. In this study, analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 but not MPK3 or MPK6. Experiments performed using a kinase-impaired version of MEKK1 (K361M) showed that the kinase activity of MEKK1 may not be required for flg22-induced MPK4 activation or for other macroscopic FLS2-mediated responses. MEKK1 may play a structural role in signaling, independent of its protein kinase activity. mekk1 knockout mutants display a severe dwarf phenotype, constitutive callose deposition, and constitutive expression of pathogen response genes. This dwarf phenotype was largely rescued by introduction into mekk1 knockout plants of either the MEKK1 (K361M) construct or a nahG transgene that degrades salicylic acid. When treated with pathogenic bacteria, the K361M plants were slightly more susceptible to an avirulent strain of Pseudomonas syringae and showed a delayed hypersensitive response, suggesting a role for MEKK1 kinase activity in this aspect of plant disease resistance. Our results indicate that MEKK1 acts upstream of MPK4 as a negative regulator of pathogen response pathways, a function that may not require MEKK1's full kinase activity.

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A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana.

Abstract: We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase (MAPK)

Cited by 465 publications

References 48 publications

MAPK cascades and major abiotic stresses

MAPK cascades and major abiotic stresses

SALT-RESPONSIVE ERF1 Regulates Reactive Oxygen Species-Dependent Signaling during the Initial Response to Salt Stress in Rice

MEKK1 Is Required for flg22-Induced MPK4 Activation in Arabidopsis Plants

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