A gene editing approach for chronic hepatitis B: elimination of hepatitis B virus in vivo by targeting cccDNA and integrated viral genomes with a sequence-specific ARCUS nuclease

Gorsuch, Cassandra L.; Nemec, Paige S.; Yu, Mei; Xu, Simin; Han, Dong; Smith, Jeff; Lape, Janel; Buuren, Nicholas van; Ramírez, Ricardo; Muench, Robert; Holdorf, Meghan; Feierbach, Becket; Falls, Greg; Holt, J. D.; Shoop, Wendy; Sevigny, Emma; Karriker, Forrest; Brown, Robert S.; Joshi, Amod; Goodwin, Tyler J.; Tam, Ying K.; Lin, Paulo J.C.; Semple, Sean; Leatherbury, Neil; Delaney, William E.; Jantz, Derek; Harrison, Emily; Smith, Amy

doi:10.1016/s0168-8278(23)00491-9

Journal of Hepatology

2023

DOI: 10.1016/s0168-8278(23)00491-9

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A gene editing approach for chronic hepatitis B: elimination of hepatitis B virus in vivo by targeting cccDNA and integrated viral genomes with a sequence-specific ARCUS nuclease

Cassandra L. Gorsuch¹,

Paige S. Nemec²,

Mei Yu³

et al.

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A gene editing approach for chronic hepatitis B: elimination of hepatitis B virus in vivo by targeting cccDNA and integrated viral genomes with a sequence-specific ARCUS nuclease

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