A gene–diet interaction controlling relative intake of dietary carbohydrates and fats

Nelson, Nnamdi G.; Wu, Lili; Maier, Matthew T.; Lam, Diana L.; Cheang, Rachel T.; Alba, Diana; Huang, Alyssa; Neumann, Drexel A.; Hill, Tess; Vagena, Eirini; Barsh, Gregory S.; Medina, Marisa W.; Krauss, Ronald M.; Koliwad, Suneil K.; Xu, Allison

doi:10.1016/j.molmet.2022.101442

Cited by 7 publications

(4 citation statements)

References 51 publications

(69 reference statements)

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“…While dietary macronutrients (i.e. fat and sugar) engage divergent pathways to communicate with the CNS, we show that alterations to hypothalamic circuitry, specifically AgRP neurons, follow similar mechanistic responses and may present attractive treatment options, especially in an obesogenic food environment that promotes over consumption of many macronutrients [5,[54][55][56].…”

Section: Introductionmentioning

confidence: 87%

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

et al. 2023

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Background/Objective As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity. Methods Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice. Results While mice given sugar-sweetened water do not gain significant weight, they do show subtle differences in body composition and caloric intake. When given sugar-sweetened water, mice show similar alterations to AgRP neuronal excitability as in high-fat diet obese models. Increased sugar consumption also primes mice for increased caloric intake and weight gain when given access to a HFD. Conclusions Our results show that elevated sucrose consumption increased activity of AgRP neurons and altered synaptic excitability. This may contribute to obesity in mice and humans with access to more palatable (HFD) diets.

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Section: Introductionmentioning

confidence: 87%

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

et al. 2023

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“…Metabolic studies were performed as previously described [ [27] , [28] , [29] ]. In brief, during metabolic monitoring, mice were singly housed for 3 days before measurements were taken and allowed one day to acclimatize in CLAMS chambers (Oxymax®-CLAMS; Columbus Instruments.).…”

Section: Methodsmentioning

confidence: 99%

Identification of AgRP cells in the murine hindbrain that drive feeding

Bachor,

Hwang,

Yulyaningsih

et al. 2024

Molecular Metabolism

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“…[141][142][143] Furthermore, such an I-TENG-based monitoring system could be expanded to other cardiovascular-related diseases, such as diabetes and obesity, as well as to daily monitoring of patients' diet, alcohol consumption, and other metabolic factors in the prevention and proactive treatment of cardiovascular diseases. [144][145][146][147][148][149][150] For the cardiovascular healthcare systems, as reviewed in the previous sections, implantable self-powered therapeutic devices provide promising aspects within the ever-evolving IoT and the ever-increasing demand for personalized healthcare [151] (Figure 7a). Such point-to-point care system tackles the issue of time and money consuming of traditional cardiovascular healthcare systems.…”

Section: Conclusion and Prospectivementioning

confidence: 99%

Implantable Triboelectric Nanogenerators for Self‐Powered Cardiovascular Healthcare

Che

O'Donovan

Xiao

et al. 2023

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Triboelectric nanogenerators (TENGs) have gained significant traction in recent years in the bioengineering community. With the potential for expansive applications for biomedical use, many individuals and research groups have furthered their studies on the topic, in order to gain an understanding of how TENGs can contribute to healthcare. More specifically, there have been a number of recent studies focusing on implantable triboelectric nanogenerators (I‐TENGs) toward self‐powered cardiac systems healthcare. In this review, the progression of implantable TENGs for self‐powered cardiovascular healthcare, including self‐powered cardiac monitoring devices, self‐powered therapeutic devices, and power sources for cardiac pacemakers, will be systematically reviewed. Long‐term expectations of these implantable TENG devices through their biocompatibility and other utilization strategies will also be discussed.

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A gene–diet interaction controlling relative intake of dietary carbohydrates and fats

Cited by 7 publications

References 51 publications

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

Identification of AgRP cells in the murine hindbrain that drive feeding

Implantable Triboelectric Nanogenerators for Self‐Powered Cardiovascular Healthcare

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