A GC/MS–MS Versus GC/HRMS Dioxin Analysis Comparison. Some Critical Considerations for Low-Level Environmental Samples

Palmiotto, Marinella; Colombo, Andrea; Davoli, Enrico

doi:10.1016/b978-0-444-62623-3.00019-8

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…While other less expensive methods have been and currently are being considered for these analyses, such as triple quadrupole‐based GC/MS/MS or bioassays, alternative approaches have primarily been approved only for screening applications. For example, the European Union permits alternative methods for screening dioxins in food or feed samples (Palmiotto, Colombo, & Davoli, 2013). Nevertheless, the ability of HRMS to probe narrow mass profiles in conjunction with highly sensitive selected ion monitoring, in a manner that can detect unresolved interferents coeluting with the analyte, based on a small shift in the center of mass in the data profile, continues to be the most effective way to minimize false positives caused by difficult to resolve contaminants at these very low levels.…”

Section: Validation Of the Ms Methodsmentioning

confidence: 99%

The Development of a High‐resolution Mass Spectrometry Method for Ultra‐trace Analysis of Chlorinated Dioxins in Environmental and Biological Samples Including Viet Nam Era Veterans

Lay

Liyanage

Gidden

2020

Mass Spectrometry Reviews

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Chlorinated dioxins are labeled and recognized by both the World Health Organization and the United Nations Environmental Programme (UNEP) as “persistent organic pollutants”. Their potential for high toxicity is one of the primary factors behind intense public and regulatory scrutiny and the need to measure the compounds at very low limits, specifically the isomer 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (2,3,7,8‐TCDD). This article highlights the early mass spectrometry methods to investigate, detect, confirm, and quantify chlorinated dioxins and the initial applications involving human biomonitoring, as attempts were made to attribute health effects to TCDD exposure. This effort represented a complex and difficult scientific response to the pressing need to investigate expected exposures and alleged subsequent medical effects, which in the case of the Viet Nam veterans was being attempted a decade or more after their exposure. It is noteworthy that this method and its development touched on delicate issues involving human subjects, war veterans, environmental contamination, and was difficult not only scientifically, but for ethical and political reasons as well. Stable‐isotope dilution with analysis by gas chromatography/high‐resolution mass spectrometry (GC/HRMS) became the method of choice because of its ability to monitor characteristic ions and isotope ratios to quantify and qualify/confirm the analyte in the presence of coextracting and coeluting interferences at these low levels with the highest possible confidence. This method was rigorously tested and validated before it was used to discover and monitor levels in the environment and in various populations at then unprecedented low levels. These early studies demonstrated the feasibility of monitoring dioxins in humans even decades after exposure, and led to the detection of 2,3,7,8‐TCDD in the general population as well as specific overexposed populations. These studies also provided strong evidence regarding the origins of the 2,3,7,8‐isomer in the environment. © 2020 John Wiley & Sons Ltd. Mass Spec Rev

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Section: Validation Of the Ms Methodsmentioning

confidence: 99%