A gated sine wave blood flowmeter

Westersten, Allan; Herrold, George; Assali, N.S.

doi:10.1152/jappl.1960.15.3.533

Cited by 21 publications

(6 citation statements)

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“…The cause of the increase in the fetal arterial pressure and of the bradycardia observed during hypoxia or after occlusion of the 8 have suggested an initial vagal stimulation followed by direct effects of hypoxia on the heart. Born et al 2 believe that catecliolamijie secretion might play a significant role.…”

Section: Discussionmentioning

confidence: 99%

“…Regional blood flows were mensured with guted sinewave electromagnetic flowmeters described by Westersten, Herrold, and Assali. 8 The physical characteristics and calibration curves of this instrument have been published elsewhere. 8 The flow transducers were specially designed for each vessel under study so that a perfect fit could be obtained between the vessel wall and the transducer.…”

Section: Circulation Research Volume XI September 198smentioning

confidence: 99%

“…8 The physical characteristics and calibration curves of this instrument have been published elsewhere. 8 The flow transducers were specially designed for each vessel under study so that a perfect fit could be obtained between the vessel wall and the transducer. The procedure was as follows: The ewes were starved for 24 hours.…”

Section: Circulation Research Volume XI September 198smentioning

confidence: 99%

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Hemodynamic Changes in Fetal Lamb in Utero in Response to Asphyxia, Hypoxia, and Hypercapnia

Assali

Holm

Sehgal

1962

Circulation Research

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The effects of hypoxia (administration of 10 per cent O 2 in N 2 and constriction of the uterine arteries), of hypercapnia (administration of 8 per cent CO 2 in air), and of asphyxia (obstruction of the umbilical circulation) were studied on the fetus in utero in near-term pregnant ewes under spinal anesthesia. Hypoxia and hypercapnia produced increases in the maternal arterial pressure, maternal heart rate, and uterine blood flow. Fetal arterial pressure and carotid and umbilical blood flows increased, while the fetal heart rate decreased. Fetal femoral flow decreased during hypoxia and increased during hypercapnia. There was a delay of five to six minutes between the initiation of hypoxia or hypercapnia and the appearance of fetal circulatory changes. Transient reduction of uterine blood flow evoked insignificant hemodynamic alterations in the mother and fetus. A reduction of flow greater than 50 per cent of control values produced a fetal bradycardia along with increases in fetal arterial pressure, carotid and umbilical flows. Constriction of the umbilical veins with the umbilical arteries intact produced a prompt bradycardia together with a decrease in fetal arterial pressure and regional blood flows. Constriction of the umbilical arteries alone also produced a bradycardia with an initial rise in arterial pressure and carotid flow. Similar changes were observed after cutting the umbilical cord. Elimination of the low resistance of the placenta played a major role in these changes. Placing the lamb in the head-down position caused a marked increase in carotid blood flow without greatly modifying arterial pressure.

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Section: Discussionmentioning

confidence: 99%

Section: Circulation Research Volume XI September 198smentioning

confidence: 99%

Section: Circulation Research Volume XI September 198smentioning

confidence: 99%

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Hemodynamic Changes in Fetal Lamb in Utero in Response to Asphyxia, Hypoxia, and Hypercapnia

Assali

Holm

Sehgal

1962

Circulation Research

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“…Arterial pressure was measured with a Statham strain gauee connected with a polyethylene tube to a carotid or a femoral arterv. A previously described gated sinewave electromagnetic flowmeter 10 was used to measure the blood flow to the following regions: (a) common carotid artery exposed through a midline incision in the neck; (b) renal artery exposed through a right flank incision; (c) uterine artery exposed through a right or left inguinal incision; and (d) internal iliac or femoral artery also exposed through an inguinal incision.…”

mentioning

confidence: 99%

Regional Flow-Pressure Relationship in Response to Angiotensin in the Intact Dog and Sheep

Assali

Westersten

1961

Circulation Research

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The effects of intravenous administration of angiotensin on the arterial pressure and on the renal, carotid, iliac, uterine, and femoral blood flows were investigated in dogs and sheep through the use of implanted electromagnetic flowmeters. The rise in arterial pressure was immediate and, within the range of doses employed, presented little relation ship to the dose. The pressor effect of angiotensin was accompanied by a consistent fall in the renal blood flow and a rise in the femoral, iliac, and uterine flows. Carotid flow was less affected. These studies demonstrate the specificity of flow response to a given change in pressure in the various areas of the body.

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“…This paper presents observations made on the influence of certain commonly employed surgical manoeuvres upon arterial flow through cervical carotid arteries, utilizing, simultaneously, two electromagnetic flow meters of a design recently described by Westersten, Herrold, and Assali (1960). METHODS The data were collected from one dog, one cat, four monkeys, and two patients.…”

mentioning

confidence: 99%

A preliminary report of experimental and clinical observations upon cervical carotid artery blood flow

We¹

1962

Journal of Neurology, Neurosurgery & Psychiatry

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A gated sine wave blood flowmeter

Cited by 21 publications

References 0 publications

Hemodynamic Changes in Fetal Lamb in Utero in Response to Asphyxia, Hypoxia, and Hypercapnia

Hemodynamic Changes in Fetal Lamb in Utero in Response to Asphyxia, Hypoxia, and Hypercapnia

Regional Flow-Pressure Relationship in Response to Angiotensin in the Intact Dog and Sheep

A preliminary report of experimental and clinical observations upon cervical carotid artery blood flow

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