A gastrointestinal stromal tumor in the stomach: usefulness of computed tomographic volumetry

Hashiba, Takahiro; Oda, Kazuhiro; Koda, Keiji; Takiguchi, Nobuhiro; Seike, Kazuhiro; Miyazaki, Masaru

doi:10.1007/s10120-004-0302-7

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Per cutaneous biopsies are acceptable for inoperable tumours. 10 GISTs are known as immunoreactive for KIT (gene) which is a marker of ICC present in the myenteric plexus of stomach and small intestine. KIT (gene) is a part of the tyrosine kinase receptor complex which is detected to contain transmembrane receptor CD117.…”

Section: Discussionmentioning

confidence: 99%

GIST a rare abdominal tumor and our surgical experience

et al. 2022

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Background: GISTs are rare abdominal tumors, encountered as the most common mesenchymal neoplasms of the gastrointestinal (GI) tract leading to GI bleeding. We report a changing trend of diagnosis and management in Indian patients.Methods: The retrospective data was collected from medical records and 62 cases of GIST from 2003 to 2020 in General surgical unit of BHU. They were divided in three groups. In group A (36) patients only surgery, group B (14) patients surgery than adjuvant chemotherapy and in group C (12) who received neoadjuvant chemotherapy then surgery. Preoperatively, USG and CT scans of the abdomen were the main investigations, others being upper gastrointestinal endoscopy and chest x-ray confirm by histopathological and immunohistochemical evaluation.Results: The mean age at presentation was 42.8 years (range 17-74 years) and mean duration of symptoms was of 5 months (range 10 days-2 years). It was from the stomach, (06) duodenum (14) jejunum, (06) ileum, (1) caecum and (4) from the mesentery and (4) from retroperitoneum. 44 cases had low grade benign tumors and 18 malignancies. In group A, 22 (61%) patients showed recurrence in group B, 06, (42%) patients showed recurrence and group C, 02 (33%) patient showed recurrence.Conclusions: Most of the tumours were benign and surgical resection is the mainstay of treatment. However, the patients in which only surgery was done showed maximum recurrence and patients who received neoadjuvant chemotherapy then surgery followed adjuvant chemotherapy showed minimum recurrence.

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Section: Discussionmentioning

confidence: 99%

GIST a rare abdominal tumor and our surgical experience

et al. 2022

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“…The definition of a GIST has been changing with immunohistochemical and molecular technical advances [8]. It is widely accepted that a GIST is a mesenchymal tumor that expresses the c-kit oncoprotein or has a mutation in either the c-kit or the platelet-derived growth factor receptor-alfa (PDGFRA) gene [9].…”

Section: Discussionmentioning

confidence: 99%

“…Only a few reports described the coincidence of consumption coagulopathy and angiomatous tumor associated with KMP in the adulthood [7,15]. Moreover, although KMP is believed to be caused by clotting and fibrinolysis within giant hemangiomas and despite several cases of giant GIST of the stomach being reported, no case of concomitant gastric GIST and KMP has been reported thus far [8]. Because the predisposition to bleeding (observed in KMP) is the primary cause of death, aggressive treatment is required.…”

Section: Discussionmentioning

confidence: 99%

A rare case of concomitant huge exophytic gastrointestinal stromal tumor of the stomach and Kasabach-Merritt phenomenon

et al. 2007

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“…Upper gastrointestinal barium studies, small bowel follow-through, and barium enema were frequently performed in the past; however, now they are being replaced with endoscopy and sectional imaging examinations. GISTs are depicted as submucosal tumors with spherical ridges and normal mucosal surface when they grow endophytically [ 40 ]. This modality does not enable imaging the exterior of the gastrointestinal tract lumen (e.g., the whole image of exophytic GISTs, vasculature, degeneration, and metastasis).…”

Section: Imaging Modalitymentioning

confidence: 99%

Gastrointestinal stromal tumors: a comprehensive radiological review

Inoue

Ota²,

Yamasaki

et al. 2022

Jpn J Radiol

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Gastrointestinal stromal tumors (GISTs) originating from the interstitial cells of Cajal in the muscularis propria are the most common mesenchymal tumor of the gastrointestinal tract. Multiple modalities, including computed tomography (CT), magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography, ultrasonography, digital subtraction angiography, and endoscopy, have been performed to evaluate GISTs. CT is most frequently used for diagnosis, staging, surveillance, and response monitoring during molecularly targeted therapy in clinical practice. The diagnosis of GISTs is sometimes challenging because of the diverse imaging findings, such as anatomical location (esophagus, stomach, duodenum, small bowel, colorectum, appendix, and peritoneum), growth pattern, and enhancement pattern as well as the presence of necrosis, calcification, ulceration, early venous return, and metastasis. Imaging findings of GISTs treated with antineoplastic agents are quite different from those of other neoplasms (e.g. adenocarcinomas) because only subtle changes in size are seen even in responsive lesions. Furthermore, the recurrence pattern of GISTs is different from that of other neoplasms. This review discusses the advantages and disadvantages of each imaging modality, describes imaging findings obtained before and after treatment, presents a few cases of complicated GISTs, and discusses recent investigations performed using CT and MRI to predict histological risk grade, gene mutations, and patient outcomes.

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A gastrointestinal stromal tumor in the stomach: usefulness of computed tomographic volumetry

Cited by 8 publications

References 15 publications

GIST a rare abdominal tumor and our surgical experience

GIST a rare abdominal tumor and our surgical experience

A rare case of concomitant huge exophytic gastrointestinal stromal tumor of the stomach and Kasabach-Merritt phenomenon

Gastrointestinal stromal tumors: a comprehensive radiological review

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