A Gastric Neuroendocrine Carcinoma Expressing Somatostatin in a Bearded Dragon (<i>Pogona Vitticeps</i>)

Lyons, Jeremiah A.; Newman, Shelley J.; Greenacre, Cheryl B.; Dunlap, John R.

doi:10.1177/104063871002200230

Cited by 27 publications

(30 citation statements)

References 23 publications

(31 reference statements)

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“…[39][40][41] The majority of these cases were diagnosed as neuroendocrine gastric carcinomas. Clinical signs reported with these gastric carcinomas were unspecific and included anorexia, lethargy, vomiting, and melena.…”

Section: Gastric Ulceration and Neoplasia _____mentioning

confidence: 99%

“…Clinical signs reported with these gastric carcinomas were unspecific and included anorexia, lethargy, vomiting, and melena. [39][40][41] The gastric carcinomas were highly malignant, with metastatic spread to liver being reported in most cases. [39][40][41] GI FOREIGN BODIES _________________________ GI foreign bodies have been reported in chelonians and lizards, and to a lesser degree in snakes.…”

Section: Gastric Ulceration and Neoplasia _____mentioning

confidence: 99%

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Clinical Update on Diagnosis and Management of Disorders of the Digestive System of Reptiles

Mans

2013

Journal of Exotic Pet Medicine

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Section: Gastric Ulceration and Neoplasia _____mentioning

confidence: 99%

Section: Gastric Ulceration and Neoplasia _____mentioning

confidence: 99%

Clinical Update on Diagnosis and Management of Disorders of the Digestive System of Reptiles

Mans

2013

Journal of Exotic Pet Medicine

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“…The prevalence of neoplasias in lizards in general is between 6% (Hernandez-Divers and Garner 2003) and 8.5% (Garner et al 2004). Case reports about neoplasias in bearded dragons include descriptions of an intrahepatic cholangiocarcinoma, adenocarcinoma and adenomas of the gallbladder (Jakab et al 2011), gastric neuroendocrine carcinomas (Ritter et al 2009;Lyons et al 2010), multicentric benign peripheral nerve sheath tumours (Lemberger et al 2005), a periorbital adenocarcinoma (Darrow et al 2013) and leukaemia (Suedmeyer and Turk 1996;Tocidlowski et al 2001;Garner et al 2004;Gregory et al 2004;Jankowski et al 2011). Neoplasias of the female and male genital tract in bearded dragons were reported by Heckers (2017).…”

mentioning

confidence: 99%

A survey of diseases in captive bearded dragons: a retrospective study of 529 patients

Schmidt-Ukaj¹,

Hochleithner²,

Richter³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:The aim of this clinical retrospective study was to analyse the prevalence of common disorders in 529 captive bearded dragons that were presented to three exotic animal clinics in Central Europe (Austria and Czech Republic) over a period of three years. A diagnosis was made on the basis of the presenting clinical signs and physical examination in 30.8% of the cases, whereas various additional diagnostic tests were performed in the other cases (69.2%). These included diagnostic imaging (radiography, ultrasound and computed tomography), examination of faecal samples for the presence of parasites, a blood-profile analysis, histological, as well as bacteriological and mycological examinations and necropsy. Gastrointestinal diseases (42.67%) like endoparasitism, constipation, sand ingestion, tympany and meteorism were the most common disorders. In 51.92% of the cases of constipation, endoparasites were present, whereas in 38.46% of the cases of constipation, metabolic bone diseases and imbalances in calcium and phosphorus levels were detected. Most of the analysed faecal samples (83.27%) were positive for the presence of endoparasites (48.7% pinworms, 25.39% coccidians and 16.06% flagellates). Dermatological problems (22.4%) contained skin tumours, which were observed in adult lizards (age range from three to eight years) and included spindle cell tumour on the eyelid, as well as spindle cell sarcoma, squamous cell carcinoma and melanoma on the trunk. Osteodystrophy, limb fractures and various types of necrosis on the limbs and tail were frequently observed musculoskeletal disorders (18.93%). Over half of all animals (57.14%) that underwent a blood test, showed a deviation in the calcium-phosphorus ratio, 63.98% showed hypocalcaemia and 26.71% hyperphosphataemia. Diseases of the urogenital system (9.47%) included renal diseases and dystocia. Neoplastic diseases besides skin tumours included two cases of leukaemia in 4-year-old bearded dragons, one of these with lymphoma in kidneys, lungs and liver and one ganglioneuroma in the body cavity of a bearded dragon of unknown age. Orthopaedic surgeries were most frequently performed to amputate the limbs or tail, whereas soft-tissue surgeries most often included the treatment of skin wounds and correction of cloacal prolapse, in addition to ovariectomy, salpingotomy or salpingectomy in female bearded dragons. Similar to the situation in Australia and the USA, infectious as well as non-infectious diseases are common in captive bearded dragons in Central Europe. Due to the high occurrence of endoparasitism, skin diseases and metabolic bone diseases in this present study, regular veterinary controls in bearded dragons including parasitological faecal examinations and optimisation of feeding and housing are necessary to improve the standard of health of bearded dragons kept as pet lizards in Europe.

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“…Descriptions of tumours of the GI tract in lizards are very rarely found in the scientific literature (5)(6)(7)12). So far, according to the authors' knowledge, two research papers have been published, which confirm a case of colon carcinoma in a Komodo dragon (Varanus komodoensis) and gastric neuroendocrine carcinoma in a bearded dragon (Pogona vitticeps) (6, 7).…”

Section: Resultsmentioning

confidence: 99%

First case of intestinal leiomyosarcoma in a bearded dragon: Ultrasonographic findings

Łojszczyk-Szczepaniak¹,

Śmiech²,

Chlebicka³

et al. 2016

Medycyna Weterynaryjna

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The paper presents a case of leiomyosarcoma of the gastrointestinal tract in a bearded dragon (Pogona vitticeps) with an ultrasound and histopathological description of pathological changes. According to our knowledge, leiomyosarcoma of the gastrointestinal tract and its ultrasound features have not been reported in lizards yet. A male bearded dragon (Pogona vitticeps), aged 4 years, was referred for radiological and ultrasound examination with a history of apathy and loss of appetite. A preliminary diagnosis of an advanced neoplasia process in the caudal coelomic cavity was established by diagnostic imaging methods. The owner decided to euthanize the animal and agreed to a post-mortem examination. After euthanasia, a histopathological examination was performed. In a radiological examination, an irregularly marginated radiopacity measuring 5.8 x 4.0 cm was visible in the central part of the coelom. Serosal margin details in the coelomic cavity were decreased, and differentiation of coelomic organs was impossible. An ultrasound examination confirmed a large amount of free echogenic fluid in the coelomic cavity. The liver had increased echogenicity, and a hypoechoic focal lesion was found in the right lobe. Mixed echogenicity masses were visible in the caudal coelom adjacent to the small intestinal loops. In one of the adjacent intestinal loops, a focal thickening of the small intestinal wall was observed with loss of the normal layered architecture. The mass had complex and mostly low echogenicity with a cystic lesion present in the centre. Necropsy confirmed the presence of proliferative lesions in the body cavity, originating from the intestine and infiltrating the mesentery and the lumbar spine area as well as the gonads located at this site. On the basis of the histological structure of the intestinal tumour, the neoplastic proliferation was classified, according to the WHO classification, to a group of malignant tumours with characteristics of leiomyosarcoma and arising from the smooth muscles. The ultrasonographic features of gastrointestinal leiomyosarcoma in that lizard corresponded to features found in dogs, in which such tumours occur as eccentric, poorly echogenic masses with anechoic cavities in large changes. Leiomyosarcoma in reptiles can be locally invasive as well. Metastatic foci are also possible, especially in the liver.

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A Gastric Neuroendocrine Carcinoma Expressing Somatostatin in a Bearded Dragon (Pogona Vitticeps)

Cited by 27 publications

References 23 publications

Clinical Update on Diagnosis and Management of Disorders of the Digestive System of Reptiles

Clinical Update on Diagnosis and Management of Disorders of the Digestive System of Reptiles

A survey of diseases in captive bearded dragons: a retrospective study of 529 patients

First case of intestinal leiomyosarcoma in a bearded dragon: Ultrasonographic findings

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