A ganglion-blocking action of surugatoxin from the Japanese ivory shell (Babylonia japonica)

A Ganglion Blocking Action of Toxic Substances IS-Toxin and Surugatoxin, from the Japanese Ivory Shell, Babylonia Japonica

“…Moreover, the symptoms such as dys uria noted in patients with food poisoning caused by the ivory shell are considered to re present dyskinesia of the urinary system due to blocking action of surugatoxin and IS-toxin upon the ganglion of motor nerves supplying the bladder. Both surugatoxin and IS-toxin (13,14,27) have been shown to act as specific nicotinic blocking agents not only on the sympathetic ganglion but also on the parasympathetic ganglion.…”

Bicyclic cytarabine analogues: synthesis and investigation of antitumor properties of novel, 6-aryl- and 6-alkyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one arabinosides

“…[2][3][4] Cytarabine also exhibited remarkable synergistic effect with other anticancer drugs like Daunorubicin, Vinblastin and cis-diaminodichloroplatin (II) (CDDP). 5,6 However, the main disadvantages of antitumor therapy with Cytarabine are related to its acute and chronic toxicity to internal organs [7][8][9][10][11][12] helices. 18,19 Bicyclic pyrimidine nucleoside analogues (BCNAs) are widely known for their antiviral activity against various RNA and DNA viruses such as: VZV, 20,21 HCMV, 22,23 HCV, 24,25 HBV 26 and the vaccinia virus (VACV).…”