A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature

Ghaouti, Merieme; Znati, Kaoutar; Jahid, Ahmed; Zouaidia, Fouad; Bernoussi, Z.; Fakir, Y. El; Mahassini, Najat

doi:10.1186/1746-1596-8-4

Cited by 14 publications

(16 citation statements)

References 11 publications

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“…In immunohistochemistry, primary carcinoma of the gallbladder is positive for CK7 and CEA, while metastatic RCC is negative for these antigens [22]. In contrast RCC metastasis would be positive for vimentin, pancytoceratin and CD10 but negative for CEA, CK7, chromogranin, synaptophysin and CD68, which indeed happened with our patient [1,19,23]. Isolated metastasis of RCC is preferentially treated with surgical resection after multidisciplinary review, especially for solitary or easily accessible pulmonary metastases, solitary resectable intra-abdominal metastases, especially if there is a long disease-free interval after nephrectomy, or a partial response of metastases to immunotherapy or targeted therapy [24].…”

Section: Discussionmentioning

confidence: 67%

“…More than 230 cases of metastasis to the pancreas have been described. In contrast, the gallbladder is very rarely a target for metastasis of RCC, but was occasionally involved in malignant melanoma [1,3,4], stomach, pancreas, ovary, colon, biliary duct and breast carcinomas [1]. We report the case of a male patient who developed isolated renal cell carcinoma metastasis to the gallbladder which was incidentally found while he was being treated for aggressive non-Hodgkin's lymphoma.…”

Section: Introductionmentioning

confidence: 99%

“…The most common histological type is clear cell tumor (70-75%). Papillary RCC and chromophobe RCC account for 15%-20% [1]. The most frequent sites of metastasis are lung (55%), regional lymph nodes (34%), liver (33%), bones (32%), adrenal (19%), contralateral kidney (11%) and CNS (6%) [2].…”

Section: Introductionmentioning

confidence: 99%

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Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Mitsimponas¹

2017

Ann Hematol Oncol

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Isolated gallbladder metastasis from renal cell carcinoma is a very rare clinical entity with a significant male predominance. Until now, only 22 cases have been reported in the medical literature. Most cases occurred after very prolonged disease-free intervals. We report a case of metachronous isolated gallbladder metastasis of 15 mm size in a 72 yr old gentleman, 12 years after subtotal nephrectomy of the upper pole of the right kidney for clear cell renal cell carcinoma. At the time of diagnosis, the patient suffered from concurrent aggressive B-cell non-Hodgkin's lymphoma which was treated aggressively, including autologous bone marrow transplantation. Gallbladder resection was performed after treatment of the hematological malignancy. Small polypoid structures in the gallbladder of patients with antecedents of renal cell carcinoma should prompt surgical resection even if the size in ultrasound does not reach internationally accepted intervention thresholds for benign gall bladder polyps.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Mitsimponas¹

2017

Ann Hematol Oncol

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“…Second, the reference lists of PubMed-selected metastatic RCC to gallbladder articles were screened systematically for additional studies of interest. A total of 35 related articles were selected for study [1–5, 7–9, 11, 12, 14–38]. …”

Section: Methodsmentioning

confidence: 99%

“…Metastasis to the gallbladder has been considered rare, and reported from a variety of primary sites, it usually manifests at a late and advanced stage of malignancy [1–3]. It is estimated that 30% - 40% of patients with RCC have already had synchronous metastasis at time of presentation and another 20% - 50% will develop metachronous metastasis after nephrectomy for the primary RCC [2, 4–6].…”

Section: Introductionmentioning

confidence: 99%

Metastatic polyp of the gallbladder from renal cell carcinoma

et al. 2017

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BackgroundGallbladder metastasis from renal cell carcinoma (RCC) is extremely rare. The purpose of this study is to clarify the characteristics of metastatic RCC to gallbladder.MethodsThe pooled data for analysis were collected from the case of metastatic RCC to gallbladder encountered by our institution along with sporadic cases reported in literature from 1991 to 2015.ResultsA total of 50 cases of metastatic RCC to gallbladder were recruited for study. Fifty-seven percentage of the primary RCC was from the right kidney and 43% from the left. The median interval between diagnoses of primary and metastatic RCC to gallbladder was 36 months, with the longest duration up to 324 months. Most (70%) were asymptomatic. The size of metastatic RCC to gallbladder ranged from 0.8 cm to 9 cm, with median of 2.6 cm. Majority (91%) of the metastatic RCCs presented as a polypoid mass with narrow stalk, and 82% were hypervascular lesion. The overall 1 year, 3 year and 5 year survival rate was 91.5%, 76.2% and 59.3% respectively, with a median of 26.5 months. Number of the metastatic site, timing of gallbladder metastasis, symptom, tumor size and operation type of cholecystectomy seemed to have no impact on survival.ConclusionsMetastatic RCC to the gallbladder should be taken into account for a gallbladder polypoid mass with narrow hypervascular stalk during the diagnosis and/or follow-up of primary RCC. Gallbladder metastasis from RCC is not necessarily to be an advanced stage with poor outcome, and cholecystectomy is recommended whenever possible.

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Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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The gallbladder is involved by a wide variety of non-epithelial tumors, apart from mesenchymal neoplasms. Visceral malignant melanoma develops in the biliary tract, including the gallbladder. As both primary and metastatic gallbladder melanomas may show similar of the same growth patterns, the differential diagnosis between these two conditions is often difficult. Primary gallbladder melanoma is more likely if the tumor shows a polypoid or lobulated and in particular papillary growth pattern, is a solitary lesion, and is associated with junctional activity in the adjacent mucosa. In contrast, metastatic lesions are more commonly multiple, flat, and without junctional changes. Apart from neuroendocrine tumors, other neuroectodermal neoplasms can develop as primary tumors in the gallbladder. Rare primary neoplasms in this organ include germ cell tumors, rhabdoid tumors, perivascular epithelioid cell tumors, and hemolymphatic neoplasms. Apart from malignant melanoma, numerous other malignancies can metastasize to the gallbladder, renal cell carcinoma being a particularly common metastasizing tumor. Malignant Melanoma of the Gallbladder Pathogenic Pathways Few melanocytes are present in the normal gallbladder mucosa, and it has been suggested that malignant melanomas take their origin from these cells that have spread from the neural crest to the gallbladder during oncogenesis. Primitive Neuroectodermal Tumor (PNET) of the Gallbladder Differential Diagnosis Differential diagnosis on conventionally stained sections mainly includes other small cell tumors occurring in the gallbladder, e.g., small cell carcinoma or lymphoma. Differential Diagnosis Gallbladder paraganglioma may occur as a component of multiple paragangliomas, involving the common bile duct and the liver in addition to the gallbladder (Ferrell et al. 1990).

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A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature

Cited by 14 publications

References 11 publications

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Metastatic polyp of the gallbladder from renal cell carcinoma

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

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