This article aims to optimize the interface design of a diabetes health management app, guided by the Interpretative Structural Modeling (ISM) and Matrice d’Impacts Croisés Multiplication Appliquée à un Classement (MICMAC) models. Through a literature review, 10 key factors influencing app interfaces were identified, and their importance, hierarchical structure, and MICMAC results were extensively studied. Targeted interface recommendations are proposed to meet the specific needs of diabetes patients, ultimately enhancing their quality of life and health.