A future perspective on neurodegenerative diseases: nasopharyngeal and gut microbiota

Khan, Farah; Oloketuyi, Sandra Folarin

doi:10.1111/jam.13327

Cited by 18 publications

(9 citation statements)

References 167 publications

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“…Approximately 60% of the bacterial genera present in our intestine form spores which likely facilitates their host-to-host transmission [26]. Furthermore,three rapid PCR-based methods, the terminal-restriction fragment length polymorphism (T-RFLP) [27] and the temperature/denaturing gradient gel electrophoresis (DGGE/TGGE) [28,29] are used to generate a fingerprint of an unknown microbial community to provide a good basis for comparing communities, however these methods are now largely replaced by high throughput sequencing above mentioned [30]. Finally, flow cytometry has long been appreciated as a technology that delivers multi-parametric information on the single cell level at a high throughput and with the opportunity for physical separation of cells (FACS sorting).…”

Section: Technological Advances To Investigate the Gut Microbiota Andmentioning

confidence: 99%

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Iannone

Preda

Blottière

et al. 2019

Expert Review of Neurotherapeutics

124

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Microbiota-gut brain axis involvement in neuropsychiatric disorders Background The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the complex gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene-environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments. Areas covered To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration and combination of data from existing gut microbiome/microbiota projects and appropriate other International "-Omics" studies. We also evaluated the new technological advances to investigate the microbiome and evidence-based treatment modulating the gut microbiota through nutritional and other interventions. Expert Opinion The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviours which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.

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Section: Technological Advances To Investigate the Gut Microbiota Andmentioning

confidence: 99%

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Iannone

Preda

Blottière

et al. 2019

Expert Review of Neurotherapeutics

124

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“…The link between PD and nasal microbiota has been examined. The results indicated that the dysbiosis of the nasopharyngeal microbiota creates the inflammatory response to α-synuclein that ends in neurodegenerative disorders [ 140 , 141 ]. The accumulation and aggregation of α-synuclein in the dopaminergic substantia nigra of the CNS cause a neuronal loss in PD [ 142 ].…”

Section: Olfactory Dysfunction and Neurological Disordersmentioning

confidence: 99%

Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging—A Review

et al. 2022

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The nasal region is one of the distinct environments for the survival of various microbiota. The human microbial niche begins to inhabit the human body right from birth, and the microbiota survive as commensals or opportunistic pathogens throughout the life of humans in their bodies in various habitats. These microbial communities help to maintain a healthy microenvironment by preventing the attack of pathogens and being involved in immune regulation. Any dysbiosis of microbiota residing in the mucosal surfaces, such as the nasal passages, guts, and genital regions, causes immune modulation and severe infections. The coexistence of microorganisms in the mucosal layers of respiratory passage, resulting in infections due to their co-abundance and interactions, and the background molecular mechanisms responsible for such interactions, need to be considered for investigation. Additional clinical evaluations can explain the interactions among the nasal microbiota, nasal dysbiosis and neurodegenerative diseases (NDs). The respiratory airways usually act as a substratum place for the microbes and can act as the base for respiratory tract infections. The microbial metabolites and the microbes can cross the blood–brain barrier and may cause NDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and multiple sclerosis (MS). The scientific investigations on the potential role of the nasal microbiota in olfactory functions and the relationship between their dysfunction and neurological diseases are limited. Recently, the consequences of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) in patients with neurological diseases are under exploration. The crosstalk between the gut and the nasal microbiota is highly influential, because their mucosal regions are the prominent microbial niche and are connected to the olfaction, immune regulation, and homeostasis of the central nervous system. Diet is one of the major factors, which strongly influences the mucosal membranes of the airways, gut, and lung. Unhealthy diet practices cause dysbiosis in gut microbiota and the mucosal barrier. The current review summarizes the interrelationship between the nasal microbiota dysbiosis, resulting olfactory dysfunctions, and the progression of NDs during aging and the involvement of coronavirus disease 2019 in provoking the NDs.

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“…Дистанционные взаимодействия поддерживаются за счет обмена метаболитами (сигнальными молекулами микробиотического происхождения) [39,40]. ГАМК -антистрессорный медиатор, продуцируется в больших количествах бактериальной микрофлорой, особенно бифидобактериями, образует единый пул с эндогенной фракцией ГАМК и непосредственно воздействует на нервные окончания в ЖКТ, стимулируя также эпителиальные клетки кишечника, которые высвобождают молекулы, модулирующие нейропередачу в энтеральной нервной системе, оказывая влияние на мозг и поведение макроорганизма [41][42][43][44].…”

Section: регуля торные метаболиты симбиотических бактерийunclassified

Gut Microbiome in Stress-related Disorders: The New Approaches to Neuroinflamation syndrome

Khalturina

Klueva

Boshiyan

et al. 2022

jour

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The review presents modern ideas about changes in the quantitative and qualitative composition of the human intestinal microbiome and their role in the development of stress-induced mental and neurological disorders, eating disorders, autism, etc. The dualism of the role of the commensal representatives of the microbiome, which have the ability to modulate metabolic and signaling reactions in conditionally healthy people and patients suffering from various neurological, psychoemotional and cognitive disorders associated with the development of neuroinflammation, is shown. The favorable and negative effects established by foreign researchers are associated with the presence of specific surface membrane proteins in the intestinal microbiota, the production of certain short-chain fatty acids, mucin degradation, changes in the intestinal barrier function, endotoxin production, as well as the synthesis of certain neurotransmitters. The prospects and difficulties of searching for new microbial biomarkers for predicting the development of stress-induced diseases, as well as for creating new microbial nutraceuticals and new-generation medicines based on living bacteria are considered.

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A future perspective on neurodegenerative diseases: nasopharyngeal and gut microbiota

Cited by 18 publications

References 167 publications

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging—A Review

Gut Microbiome in Stress-related Disorders: The New Approaches to Neuroinflamation syndrome

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