Abstract:SummaryA further synthetic approach to 2,5-trimethylenenorbornane (1; tricyclo- [5.3.0.03,9]decane, 4-homotwistbrendane), a member of the 'adamantaneland', is described starting from methyl 5-0x0-2endo-norbornanecarboxylate (5). The required C2-chain was introduced by a Wittig-Horner reaction and the ring closure of the trimethylene bridge achieved by an acyloin condensation.In the course of our studies on isomeric tricyclic hydrocarbons of the 'adamantaneland' '), we recently described a first synthesis of th… Show more
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