A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populations

Abstract

-A detailed quantitative trait locus (QTL) analysis of growth and fatness data from a three generation experimental cross between Large White (LW) and Meishan (MS) pig breeds was carried out to search for sex × QTL interactions, imprinting effects and multiple linked QTLs. A total of 530 F 2 males and 573 F 2 females issued from 6 F 1 boars and 23 F 1 sows were typed for a total of 137 markers covering the entire porcine genome. Nine growth traits and three backfat thickness measurements were analysed. All analyses were performed using line cross regression procedures. A QTL with sex-specific expression was revealed in the proximal region of chromosome 8, although some confusion between herd and sex effects could not be discarded. This previously undetected QTL affected male growth during the fattening period, with a favourable additive effect of the LW allele. The analyses also revealed the presence of two linked QTLs segregating on chromosome 1, affecting growth traits during the post-weaning period. The first QTL, previously detected using a single QTL model, was located at the end of the q arm of chromosome 1 and had a favourable MS allele. The second QTL had a favourable LW allele and was located in the proximal extremity of the q arm of chromosome 1. Suggestive genomic imprinting was found in the distal region of chromosome 9 affecting growth during the fattening period.pig / growth / sex-QTL interaction / imprinting / linked QTLs

Characterization of the porcine differentially expressed PDK4 gene and association with meat quality

“…Alignment between pig chromosome 9 on RH map and human maps on USDA-MARC Pig Database [23], we found some QTLs associated with meat quality and production traits in this region such as body weight at 10 weeks of age (87 cM) [24], average backfat thickness (79.3-90 cM) [25], total saturated fatty acids (61.5-83.3 cM) [26], backfat at tenth rib (96-79 cM) [27]. Also, PDK4 had thought to be a key regulatory enzyme involved in switching the energy source from glucose to fatty acids in response to physiological conditions [17].…”

Malic enzyme 1genotype is associated with backfat thickness and meat quality traits in pigs

“…1999; Milan et al. 2002), but the existence of more than one QTL cannot be ruled out (Rohrer 2000; Quintanilla et al. 2002).…”

Molecular characterization and chromosomal mapping of porcine adipose differentiation‐related protein (ADRP)

“…The best marker order of the ADRP gene between linked markers produced by a multipoint linkage analysis: SW2185-13.0-ADRP-5.0-SW1970-18.0-SW974 (numbers between markers indicate distance, cM). Several studies have reported QTL affecting growth and fat deposition traits in this region containing the porcine ADRP locus (Knott et al 1998;Rohrer & Keele 1998;De Koning et al 1999;Bidanel et al 2001;Quintanilla et al 2002).…”