A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography

Yamada, Satoshi; Komuro, Kaoru; Taniguchi, Mariko; Uranishi, Ayumi; Komatsu, Hiroshi; Asanuma, Toshihiko; Ishikura, Fuminobu; Onozuka, Hisao; Mikami, Taisei; Tsutsui, Hiroyuki; Beppu, Shintaro

doi:10.1007/s10396-006-0089-8

Cited by 3 publications

(1 citation statement)

References 16 publications

(24 reference statements)

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“…[1][2][3] The patient showed a dramatic decrease in the pressure gradient in the outfl ow tract on the injection of ethanol. Myocardial contrast enhancement of the localized area promised a successful result following ethanol injec- Keywords percutaneous transluminal septal myocardial ablation (PTSMA) · contrast echo · hypertrophic obstructive cardiomyopathy…”

Section: Discussionmentioning

confidence: 96%

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy

et al. 2008

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Katsufumi MIZUSHIGE · Kazushi MURAKAMI Teppei TSUJI · Isao KONDO · Xie LU Atsufumi TOMOHIROPercutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy was carefully introduced into a small branch perforating the hypertrophic site of the interventricular septum. Contrast agent produced using the manual agitation method was injected from the tip of the balloon catheter. Simultaneously, a left ventricular long-axis view from the cardiac apex was taken with a low gain setting of the ultrasonograph. The hypertrophic site of the interventricular septum was visualized as a brightened mass (Fig. 2) immediately after the echo contrast agent was injected. Ethanol was slowly injected through the tip of the balloon catheter superselectively inserted into the perforating branch of the LAD.During the follow-up period, reduction of the pressure gradient in the left ventricular outfl ow tract was demonstrated on continuous-wave Doppler fl owmetry and two-dimensional echocardiography (Fig. 3). Systolic anterior motion disappeared on M-mode echocardiography, although the aortic regurgitation jet image became clearer than that acquired at the time of the preoperative examination. The grade of regurgitation was not suffi cient to infl uence the clinical course. DiscussionPercutaneous transluminal septal myocardial ablation (PTSMA) is a semi-invasive treatment using a catheter technique in patients with hypertrophic obstructive cardiomyopathy. The success rate of this method depends on the location of the hypertrophic site. In our patient, the hypertrophic site was extremely localized in the outfl ow tract of the interventricular septum. Since myocardial damage can be limited in a small area, we were able to avoid any advanced event of bradyarrhythmia or fatal damage of left ventricular function.Myocardial contrast echocardiography is feasible as a method for deciding an adequate area for injection of ethanol. 1-3 The patient showed a dramatic decrease in the pressure gradient in the outfl ow tract on the injection of ethanol. Myocardial contrast enhancement of the localized area promised a successful result following ethanol injecKeywords percutaneous transluminal septal myocardial ablation (PTSMA) · contrast echo · hypertrophic obstructive cardiomyopathy Case presentationA 69-year-old woman was referred to our hospital because of dyspnea and a sensation of pressure in her chest during exertion. She had been under treatment with a Ca channel blocker and diuretics for systemic hypertension. Her blood pressure was 120/60 mmHg and her pulse rate was 84 beats/ min. Cardiac examination revealed a grade III/VI systolic ejection murmur in the 4th left sternal border. An electrocardiogram showed normal sinus rhythm and left ventricular hypertrophy, and a chest X-ray fi lm showed mild cardiomegaly. Transthoracic echocardiography was carried out. Localized hypertrophy of the interventricular septum produced a marked obstruction in the left ventricular outfl ow tract, and systolic anterior motion was reveal...

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Section: Discussionmentioning

confidence: 96%

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy

et al. 2008

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Relation between myocardial blood volume and left ventricular contractile reserve in patients with dilated cardiomyopathy

Yamada¹,

Iwano²,

Komuro³

et al. 2010

Jpn J Med Ultrasonics

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tion, but it signifi cantly correlated with percent change in LVEF during dobutamine stress echocardiography r 0. 54 , p 0. 01 . Myocardial histomorphometric features in patients with DCM conceivably cause the reduction in myocardial blood volume, being related to the depressed contractile reserve. Conclusion : Myocardial blood volume measured by MCE was associated with LV con tractile reserve in patients with DCM.

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Quantitative Assessment of Tissue Perfusion in Hepatocellular Carcinoma Using Perflubutane Dynamic Contrast-Enhanced Ultrasonography: A Preliminary Study

et al. 2015

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Our purpose in this study was to assess the relationship between contrast signal intensity (CI) and concentration of perflubutane microbubbles in a phantom experiment, and to examine the feasibility of this technique for quantitative analysis of vascularity in hepatocellular carcinoma (HCC). Microbubble solutions of the perflubutane contrast agent were prepared by mixing with purified water. We examined the relationship between CI in dB units and the concentration. Moreover, seven HCC patients were examined using real-time dynamic contrast imaging. The perfusion index was calculated from time-intensity curves generated for both HCC and surrounding liver parenchyma. We observed a linear relationship between the CIdB and the concentration in the phantom study and a higher perfusion index in the HCC lesions relative to the surrounding liver parenchyma. Dynamic contrast-enhanced ultrasonography with perflubutane microbubbles, which exhibit linear and temporally stable characteristics under continuous ultrasound exposure, allows the collection of quantitative hemodynamic information regarding HCC.

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A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography

Abstract: In low-MI contrast ultrasonography, the power of CI is proportional to contrast concentration, and CI in dB is logarithmic to the concentration. Thus, the microbubble concentration can be quantitatively measured even in low-MI contrast ultrasonography.

Cited by 3 publications

References 16 publications

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy

Relation between myocardial blood volume and left ventricular contractile reserve in patients with dilated cardiomyopathy

Quantitative Assessment of Tissue Perfusion in Hepatocellular Carcinoma Using Perflubutane Dynamic Contrast-Enhanced Ultrasonography: A Preliminary Study

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