A functional variant in the 5′‐flanking region of the chicken serotonin transporter gene is associated with increased body weight and locomotor activity

Phi‐van, Loc; Holtz, Marlis; Kjaer, Joergen; Phi, Valerie D. van; Zimmermann, Katrin

doi:10.1111/jnc.12799

Cited by 14 publications

(21 citation statements)

References 40 publications

(43 reference statements)

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“…To construct plasmids p908HTT-Luc and p577HTT-Luc, the Xba IXho I fragments containing the sequences − 908/+ 78 and − 577/ +78 of the 5-HTT gene, isolated from pW5HTTCAT [35] and p0.63HTT-CAT [9], respectively, were introduced into pGL3-basic between the Nhe I and Xho I sites.…”

Section: Recombinant Plasmidsmentioning

confidence: 99%

Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells

van¹,

Mühlbauer²,

Phi‐van³

2015

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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Section: Recombinant Plasmidsmentioning

confidence: 99%

Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells

van¹,

Mühlbauer²,

Phi‐van³

2015

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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“…Chickens were generated as described previously [15]. For experiments of determining feed intake, after hatching, hens were sorted and partitioned according to genotype in W/W, W/D, and D/D genotype groups.…”

Section: Methodsmentioning

confidence: 99%

“…For experiments of determining feed intake, after hatching, hens were sorted and partitioned according to genotype in W/W, W/D, and D/D genotype groups. Because D/D and W/D hens exhibited an increase in body weight gain earlier than D/D and W/D cocks [15], we used only hens for this study. In order to obtain enough data for statistical evaluation, hens of each genotype were divided into 6 independent groups (15 hens each).…”

Section: Methodsmentioning

confidence: 99%

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Evidence for the Association of a Deleted Variant in the 5′-Flanking Region of the Chicken serotonin transporter (5-HTT) Gene with a Temporary Increase in Feed Intake and Growth Rate

Kjaer

Phi‐van

2016

Animals

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Simple SummaryThe serotonergic system has been shown to be implicated in the regulation of mood and feeding behavior. Previous studies have identified a polymorphism in the 5′-flanking region of the serotonin transporter (5-HTT) gene of Lohmann Brown (LB) laying hens. In this study, the impact of three genotypes (W/W, W/D, and D/D) at the 5-HTT gene on feed intake and body weight was investigated. After hatching, hens of the three genotypes were kept under ad libitum feeding conditions, and their feed intake and body weight were recorded weekly. From 5 weeks of age, D/D and W/D hens were significantly heavier than wild-type W/W hens. Further, it is found that D/D hens had a temporarily higher feed intake and growth rate than W/W hens between 4 and 7 weeks. We suggest that the increased body weight is due to a transiently increased appetite of D/D hens.AbstractThe serotonergic system has been shown to be implicated in the regulation of mood and feeding behavior. Previous studies have identified a polymorphism in the 5′-flanking region of the serotonin transporter (5-HTT) gene of Lohmann Brown (LB) laying hens. The deleted variant D was found to be associated with increased body weight. The objective of this study was to address whether the increased body weight may be due to an increased feed intake. After hatching, hens were kept under ad libitum feeding conditions, and their body weight and feed intake were weekly determined. From 5 weeks of age, the body weight of hens with the D/D and W/D genotypes was significantly greater than that of W/W carrying hens. Interestingly, we found that the feed intake of D/D carrying hens, relative to body weight, was transiently increased only between 4 and 7 weeks of age (p < 0.05), leading to a higher growth rate (p < 0.05), compared with that of W/W carrying hens. These results suggest that the presence of variant D may be correlated with a transiently increased appetite of D/D carrying hens.

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“…; Phi‐van et al . ). A most exciting observation here is that early life stress in SERT‐mutant rats compromises BDNF expression (Calabrese et al .…”

Section: Biogenic Amine Transmission Signalling and Pathobiologymentioning

confidence: 97%

Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future

Beart

2016

Journal of Neurochemistry

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This 'Past to Future' Review as part of the 60th anniversary year of the Journal of Neurochemistry focuses on synaptic transmission and associated signalling, and seeks to identify seminal progress in neurochemistry over the last 10 years which has advanced our understanding of neuronal communication in brain. The approach adopted analyses neurotransmitters on a case by case basis (i.e. amino acids, monoamines, acetylcholine, neuropeptides, ATP/purines and gasotransmitters) to highlight novel findings that have changed the way we view each type of transmitter, to explore commonalities and interactions, and to note how new insights have changed the way we view the biology of degenerative, psychiatric and behavioural conditions. Across all transmitter systems there was remarkable growth in the identification of targets likely to provide therapeutic benefit and which undoubtedly was driven by the elucidation of circuit function and new vistas of synaptic signalling. There has been an increasing trend to relate signalling to disease, notably for Alzheimer's and Parkinson's disease and related conditions, and which has occurred for each transmitter family. Forebrain circuitry and tonic excitatory control have been the centre of great attention yielding novel findings that will impact upon cognitive, emotional and addictive behaviours. Other impressive insights focus on gasotransmitters integrating activity as volume transmitters. Exciting developments in how serotonin, cholinergic, l-glutamate, galanin and adenosine receptors and their associated signalling can be beneficially targeted should underpin the development of new therapies. Clearly integrated, multifaceted neurochemistry has changed the way we view synaptic signalling and its relevance to pathobiology. Highlighted are important advances in synaptic signalling over the last decade in the Journal of Neurochemistry. Across all transmitter systems elucidation of circuit function, and notably molecular insights, have underpinned remarkable growth in the identification of targets likely to provide therapeutic benefit in neuropathologies. Another commonality was wide interest in forebrain circuitry and its tonic excitatory control. Increasingly observations relate to signalling in disease and behavioural conditions. This article is part of the 60th Anniversary special issue.

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A functional variant in the 5′‐flanking region of the chicken serotonin transporter gene is associated with increased body weight and locomotor activity

Abstract: In this study, we identified a polymorphism in the 5

Cited by 14 publications

References 40 publications

Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells

Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells

Evidence for the Association of a Deleted Variant in the 5′-Flanking Region of the Chicken serotonin transporter (5-HTT) Gene with a Temporary Increase in Feed Intake and Growth Rate

Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future

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