A functional polymorphism in Pre‐miR‐146a gene is associated with prostate cancer risk and mature miR‐146a expression in vivo

Abstract

The natural genetic variation in pre-miR-146a affects the amount of mature miR-146a, contributes to the genetic predisposition to CaP.

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

“…The distribution of all the genotypes in the controls was consistent with the HWE in all studies, except for 3 studies (Catucci et al, 2010;George et al, 2011;Mittal et al, 2011). Several studies collected information on possible confounding factors, such as smoking status (Guo et al, 2010;Xu et al, 2010;Zeng et al, 2010) and gender (Xu et al, 2008;Zeng et al, 2010;Akkiz et al, 2011), and the gene-environment interaction effect was ana-, and the gene-environment interaction effect was anaand the gene-environment interaction effect was analyzed in subgroups. miR-146a polymorphism and cancer susceptibility…”

“…The study selection process is shown in Figure 1. Finally, 22 articles (Jazdzewski et al, 2008;Xu et al, 2008;Hoffman et al, 2009;Hu et al, 2009;Tian et al, 2009;Catucci et al, 2010;Guo et al, 2010;Liu et al, 2010;Okubo et al, 2010;Pastrello et al, 2010;Srivastava et al, 2010;Xu et al, 2010;Zeng et al, 2010;Garcia et al, 2011;George et al, 2011;Akkiz et al, 2011;Hishida et al, 2011;Mittal et al, 2011;Permuth-Wey et al, 2011;Yue et al, 2011;Zhou et al, 2011;Zhou et al, 2012) with 11,901 cases and 14,200 controls were included in the present meta-analysis. An article by Catucci et al (2010) reported a case-control study of a German population and an Italian population separately, and one by Jazdzewski et al (2008) reported studies on populations of Finland, Poland, and USA separately.…”

“…In papillary thyroid carcinoma (Pallante et al, 2006) and cervical cancer (Wang et al, 2008), the levels are increased, but reduced in prostate cancer (Volinia et al, 2006). Moreover, reports indicate that changes in miR-146a expression observed in these solid tumors are probably related to a common G/C polymorphism located in the stem-loop of pre-miR-146a (rs2910164) (Xu et al, 2010). However, association studies with small sample sizes lack statistical power and may produce conflicting conclusions.…”

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

“…Also, the expression of miR-146a in prostate cancer tissues was controlled by a common G/C polymorphism located in the stem-loop of pre-miR-146a (rs2910164). We found that subjects with the CC homozygous genotype had a 0.65-fold lower risk than those with the GG/GC genotypes, and the C allele displayed a lower prevalence of prostate cancer compared with the G allele (Xu et al, 2010). However, the prognostic role of rs2910164 in prostate cancer has not been reported.…”

miRNAs Highlights in Stem and Cancer Cells

“…Silencing of miRNA genes by DNA promoter mutation, hypermethylation and/or histone hypoacetylation has also been described in solid tumours and in haematological malignancies [197,198,199]. Saito and colleagues first…”