A functional polymorphism at miR-491-5p binding site in the 3′-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population

Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines

“…Additionally, a functional polymorphism that might affect the binding of non-coding RNAs and thus mRNA transport and translation was identified within the 3’ untranslated region of MMP-9 mRNA (Yuan et al, 2013). …”

A Single Nucleotide Polymorphism (rs1056629) in 3'-UTR of MMP-9 is Responsible for a Decreased Risk of Metastatic Osteosarcoma by Compromising its Interaction with microRNA-491-5p

“…An immunohistochemical analysis identified MMP9 to be strongly positive in metastastic lesions from children with osteosarcoma [14]. A single nucleotide polymorphism (SNP) (rs1056629) is located in the miR-491 binding site in the 3'UTR of MMP9, and it confers an increased risk for an atherosclerotic cerebral infarction [15]. We hypothesize that rs1056629 might interfere with the interaction between MMP9 mRNA and miR-491 and that the minor allele (C) might be associated with OS metastasis.…”

The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke

“…Yuan et al studied rs1056628 (A vs. C allele) in a Chinese population and noted dose-dependent increased expression of the C-allele ( p < 0.01) and CC genotype ( p < 0.05) in IS patients when compared to controls [106]. The promoter region -1562 (C vs. T allele) polymorphism was also shown to influence IS incidence with the T-allele associated with increased IS incidence (OR 1.543, 95% CI 1.144–2.080, p = 0.004) [72].…”