A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires

Diekhof, Esther K.; Keil, Maria; Obst, Katrin; Henseler, Ilona; Dechent, Peter; Falkai, Peter; Gruber, Oliver

doi:10.1016/j.brainres.2012.07.010

Cited by 51 publications

(62 citation statements)

References 67 publications

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“…In addition to these activations in mesolimbic dopaminergic brain regions, participants also showed activations in a bilateral fronto-parietal cortical network (associated with salience processing) replicating findings of previous studies (Diekhof et al, 2012;Diekhof and Gruber, 2010;Trost et al, 2014) (Supplementary Table S2).…”

Section: Fmri Datasupporting

confidence: 85%

“…Small volume analyses using a priori coordinates from our previous studies (Diekhof et al, 2012;Diekhof and Gruber, 2010) confirmed significantly reduced activations in the bilateral ventral striatum and the VTA in the risk allele carriers (FWE-corrected for small volume).…”

Section: Fmri Datasupporting

confidence: 54%

“…In both groups, activations in the reward task-related fronto-parietal network were found (Diekhof et al, 2012;Diekhof and Gruber, 2010;Trost et al, 2014). The risk allele carriers showed significantly reduced brain activation in the bilateral frontoopercular cortex/insular cortex and the right intraparietal cortex in comparison with the homozygous major allele carriers (Supplementary Table S3).…”

Section: Fmri Datamentioning

confidence: 93%

“…So, during the RC, subjects were forced to overcome the tendency to acquire immediate reward (reject the previously conditioned reward stimuli) in order to reach the superordinate long-term goal. This situation therefore constituted a 'desire-reason dilemma' (Diekhof et al, 2012;Diekhof and Gruber, 2010;Trost et al, 2014). For more information, see also Supplementary Figure S1.…”

Section: Experimental Procedure/drd Paradigmmentioning

confidence: 99%

“…FWE (family-wise error) correction was performed with respect to our a priori regions of interest (small volume analyses of the dopaminergic reward system) and on the whole brain level. Small volume analyses were applied to the bilateral ventral striatum (±12 12 − 3) and the VTA (±9 − 21 − 12) (regions of interest, 10 mm spheres centering a priori coordinates from previous studies) (Diekhof et al, 2012;Diekhof and Gruber, 2010). Further whole-brain genotype group effects were searched for using po0.001, uncorrected.…”

Section: Genotype Group Classificationmentioning

confidence: 99%

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Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Trost

Diekhof

Mohr

et al. 2016

Neuropsychopharmacol

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Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipolar disorder and schizophrenia, are linked to functional alterations in the reward system. We aimed at investigating possible effects of the MAD1L1 rs11764590 risk allele on reward systems functioning in healthy adults. A large homogenous sample of 224 young (aged 18-31 years) participants was genotyped and underwent functional magnetic resonance imaging (fMRI). All participants performed the 'Desire-Reason Dilemma' paradigm investigating the neural correlates that underlie reward processing and active reward dismissal in favor of a long-term goal. We found significant hypoactivations of the ventral tegmental area (VTA), the bilateral striatum and bilateral frontal and parietal cortices in response to conditioned reward stimuli in the risk allele carriers compared with major allele carriers. In the dilemma situation, functional connectivity between prefrontal brain regions and the ventral striatum was significantly diminished in the risk allele carriers. Healthy risk allele carriers showed a significant deficit of their bottom-up response to conditioned reward stimuli in the bilateral VTA and striatum. Furthermore, functional connectivity between the ventral striatum and prefrontal areas exerting top-down control on the mesolimbic reward system was reduced in this group. Similar alterations in reward processing and disturbances of prefrontal control mechanisms on mesolimbic brain circuits have also been reported in bipolar disorder and schizophrenia. Together, these findings suggest the existence of an intermediate phenotype associated with MAD1L1.

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Section: Fmri Datasupporting

confidence: 85%

Section: Fmri Datasupporting

confidence: 54%

Section: Fmri Datamentioning

confidence: 93%

Section: Experimental Procedure/drd Paradigmmentioning

confidence: 99%

Section: Genotype Group Classificationmentioning

confidence: 99%

See 3 more Smart Citations

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Trost

Diekhof

Mohr

et al. 2016

Neuropsychopharmacol

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Networks underlying trait impulsivity: Evidence from voxel-based lesion-symptom mapping

et al. 2016

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Impulsivity is considered a multidimensional construct that encompasses a range of behaviors, including poor impulse control, premature decision-making, and the inability to delay gratification. In order to determine the extent to which impulsivity and its components share a common network, we performed a voxel-based lesion-symptom mapping (VLSM) analysis in a large sample of patients (N=131) with focal, penetrating traumatic brain injuries (pTBI). Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11), a standard self-report measure that allows for unique estimates of global impulsivity and its factor analysis-derived components (e.g., “motor impulsivity”). Heightened global impulsivity was associated with damage to multiple areas in bilateral prefrontal cortex (PFC), left superior, middle and inferior temporal gyrus, and left hippocampus. Moreover, we identified a cluster within the left PFC associated specifically with motor impulsivity (defined as “acting without thinking”). Our results are consistent with existing literature on bilateral prefrontal cortical involvement in behavioral impulsivity, but also provide new evidence for a more complex neuroanatomical representation of this construct, characterized by left-lateralized temporal and hippocampal involvement, as well as a left-lateralized prefrontal network specifically associated with motor impulsivity.

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Influence of ventral tegmental area input on cortico‐subcortical networks underlying action control and decision making

Richter

Gruber

2017

Human Brain Mapping

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It is argued that the mesolimbic system has a more general function in processing all salient events, including and extending beyond rewards. Saliency was defined as an event that is unexpected due to its frequency of occurrence and elicits an attentional-behavioral switch. Using functional magnetic resonance imaging (fMRI), signals were measured in response to the modulation of salience of rewarding and nonrewarding events during a reward-based decision making task, the so called desire-reason dilemma paradigm (DRD). Replicating previous findings, both frequent and infrequent, and therefore salient, reward stimuli elicited reliable activation of the ventral tegmental area (VTA) and ventral striatum (vStr). When immediate reward desiring contradicted the superordinate task-goal, we found an increased activation of the VTA and vStr when the salient reward stimuli were presented compared to the nonsalient reward stimuli, indicating a boosting of activation in these brain regions. Furthermore, we found a significantly increased functional connectivity between the VTA and vStr, confirming the boosting of vStr activation via VTA input. Moreover, saliency per se without a reward association led to an increased activation of brain regions in the mesolimbic reward system as well as the orbitofrontal cortex (OFC), inferior frontal gyrus (IFG), and anterior cingulate cortex (ACC). Finally, findings uncovered multiple increased functional interactions between cortical saliency-processing brain areas and the VTA and vStr underlying detection and processing of salient events and adaptive decision making.

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A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires

Cited by 51 publications

References 67 publications

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Networks underlying trait impulsivity: Evidence from voxel-based lesion-symptom mapping

Influence of ventral tegmental area input on cortico‐subcortical networks underlying action control and decision making

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