A Functional Near-Infrared Spectroscopy Examination of the Neural Correlates of Mental Rotation for Individuals With Different Depressive Tendencies

Wang, Liusheng; Ke, Jingqi; Zhang, Haiyan

doi:10.3389/fnhum.2022.760738

Cited by 4 publications

(4 citation statements)

References 67 publications

(79 reference statements)

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“…For the oxy-hemoglobin brain areas in the minor depression group, Wang et al divided 41 college students into higher and lower depressive tendencies groups based on BDI score, higher deactivation was observed in the higher depressive tendency group for the following brain areas: the inferior frontal gyrus (BA45), the superior external frontal cortex (BA46), premotor cortex (BA6), and the primary motor cortex (BA4) [24]. This is slightly similar to the current study, as only the pars triangularis (BA45) was observed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…They found prefrontal oxygenation (right VLPFC) was lowest in MDD group with suicidality, compared with MDD group and healthy controls. Wang et al [24] divided 41 college students into higher and lower depressive tendencies groups based on their BDI scores. Higher depression groups showed higher deactivation of oxyhemoglobin (HbO) in the superior external frontal cortex (BA46), inferior frontal gyrus (BA45), premotor cortex (BA6), and primary motor cortex (BA4).…”

Section: Introductionmentioning

confidence: 99%

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Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study

Li,

Ma,

Rossbach

et al. 2024

Ann Gen Psychiatry

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Background While depression is increasing worldwide, some patients are diagnosed as having Major Depressive Disorder (MDD), but others are diagnosed with minor depression, however, the potential neuro mechanism is unknown. Methods Sixty-two patients with minor depression, 44 adolescents with MDD and 54 healthy adolescents participated in this study. Functional near-infrared spectroscopy (fNIRS), both HAMD and HAMA data were collected from all of the participants. Results The result indicates the pervasively decreased activation of BA, 11, 21, 45 and 46 were observed in the MDD group and reduced activation of BA 45 was observed in the minor depression group. However, cortical activation was not observed between the minor depression or MDD groups. Cortical activation was also not correlated with the depressive/anxious score in the minor and MDD groups separately. Conclusions Cortical activation was pervasively decreased in the MDD group and slightly reduced in the minor depression group, which may be a potential neural mechanism. As reduced cortical activation in minor depression, interventions in the early stages of minor depression may help slow or even modify the development of the illness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study

Li,

Ma,

Rossbach

et al. 2024

Ann Gen Psychiatry

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“… 9 Furthermore, emotions can impact the impairment of visuospatial working memory. 10 The long-term gastrointestinal symptoms experienced by individuals with IBD may induce anxiety, depression, and other mental disorders, consequently resulting in visuospatial memory impairment. 11 …”

Section: Introductionmentioning

confidence: 99%

“… 12 , 13 The mental rotation task (MRT) is commonly used in psychology to assess visuospatial working memory function, widely used to test visuospatial cognitive impairment. 10 Despite abnormal cognitive performance in IBD patients and compromised visual networks, 14 , 15 our understanding of VSWM deficits in IBD remains incomplete. Based on the MRT, we employed it as the task during Functional Magnetic Resonance Imaging (fMRI) scanning to evaluate VSWM in patients with IBD.…”

Section: Introductionmentioning

confidence: 99%

Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease

Guo,

Wu,

Zheng

et al. 2024

JIR

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Background Inflammatory Bowel Disease (IBD) patients may experience cognitive impairments in Visuospatial Working Memory (VSWM), significantly impacting their quality of life. However, the mechanisms underlying these impairments remain poorly understood. Methods We studied functional MRI and graph theory analysis to investigate changes in functional connectivity networks during the Mental Rotation Task (MRT) in IBD patients. Twenty IBD patients (13 males, 7 females; mean age = 34.95 ± 13.80 years; mean disease duration = 2.43 ± 2.37 years) participated in the study. Exclusion criteria encompassed recent use of analgesics, 5-Aminosalicylate, corticosteroids, or immunosuppressants within the past three months. Additionally, we recruited 20 age-, gender-, and education-matched healthy controls for comparison. Results Compared to a control group, IBD patients exhibited significantly longer reaction times and reduced accuracy during the MRT. Our analysis revealed abnormalities in multiple nodal attributes within the functional connectivity network, particularly in regions such as the bilateral orbitofrontal cortex, right supplementary motor area, bilateral parahippocampal gyrus, and bilateral anterior temporal lobe. We observed that the nodal efficiency in the left temporal pole is negatively correlated with Red Blood Cell Distribution Width (RDW) and positively correlated with response time of MRT. Conclusion Our findings revealed notable abnormalities in multiple node attributes among IBD patients during MRT, providing evidence of cognitive impairments in VSWM in IBD patients. This study found RDW maybe can serve as a clinical indicator for predicting early VSWM impairment in patients with IBD.

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Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics

Wertz,

Rüttiger,

Bender

et al. 2024

Front. Neurosci.

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The ongoing controversies about the neural basis of tinnitus, whether linked with central neural gain or not, may hamper efforts to develop therapies. We asked to what extent measurable audiometric characteristics of tinnitus without (T) or with co-occurrence of hyperacusis (TH) are distinguishable on the level of cortical responses. To accomplish this, electroencephalography (EEG) and concurrent functional near-infrared spectroscopy (fNIRS) were measured while patients performed an attentionally demanding auditory discrimination task using stimuli within the individual tinnitus frequency (fTin) and a reference frequency (fRef). Resting-state-fMRI-based functional connectivity (rs-fMRI-bfc) in ascending auditory nuclei (AAN), the primary auditory cortex (AC-I), and four other regions relevant for directing attention or regulating distress in temporal, parietal, and prefrontal cortex was compiled and compared to EEG and concurrent fNIRS activity in the same brain areas. We observed no group differences in pure-tone audiometry (PTA) between 10 and 16 kHz. However, the PTA threshold around the tinnitus pitch was positively correlated with the self-rated tinnitus loudness and also correlated with distress in T-groups, while TH experienced their tinnitus loudness at minimal loudness levels already with maximal suffering scores. The T-group exhibited prolonged auditory brain stem (ABR) wave I latency and reduced ABR wave V amplitudes (indicating reduced neural synchrony in the brainstem), which were associated with lower rs-fMRI-bfc between AAN and the AC-I, as observed in previous studies. In T-subjects, these features were linked with elevated spontaneous and reduced evoked gamma oscillations and with reduced deoxygenated hemoglobin (deoxy-Hb) concentrations in response to stimulation with lower frequencies in temporal cortex (Brodmann area (BA) 41, 42, 22), implying less synchronous auditory responses during active auditory discrimination of reference frequencies. In contrast, in the TH-group gamma oscillations and hemodynamic responses in temporoparietal regions were reversed during active discrimination of tinnitus frequencies. Our findings suggest that T and TH differ in auditory discrimination and memory-dependent directed attention during active discrimination at either tinnitus or reference frequencies, offering a test paradigm that may allow for more precise sub-classification of tinnitus and future improved treatment approaches.

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A Functional Near-Infrared Spectroscopy Examination of the Neural Correlates of Mental Rotation for Individuals With Different Depressive Tendencies

Cited by 4 publications

References 67 publications

Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study

Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study

Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease

Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics

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