A Functional MMP12 Polymorphism Is Associated with Lung Function throughout Life and Delayed Onset of COPD.

Hunninghake, G.M.; Cho, MH; Tesfaigzi, Yohannes; Soto‐Quirós, ME; Avila, Lydia; Lasky‐Su, Jessica; Lange, Christian; Dl, DeMeo; Hersh, C.P.; Klanderman, BJ; Raby, BA; Sparrow, David; Shapiro, SD; Silverman, EK; Litonjua, AA; Weiss, ST; Celedon, JC

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3004

Cited by 5 publications

(5 citation statements)

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“…[47] There is also an increased expression of MMPs in cerebrospinal fluid of AD patients. [48] Selective inhibitors for MMP12 [49] was shown to reduce inflammation and delay of atherosclerosis progression. [50,51] While observational studies demonstrated an association between high levels of plasma MMP12 and recurrent cardiovascular disease, MR yielded the inverse finding, such that genetic variants associated with higher MMP12 levels are associated with decreased risks of coronary artery disease and large artery atherosclerotic stroke, discouraging potential clinical trials of MMP12 inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization

Gong,

Williams,

Scholes

et al. 2024

Preprint

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Population-based proteomics offer a groundbreaking avenue to predict dementia onset. This study employed a proteome-wide, data-driven approach to investigate protein-dementia associations in 229 incident all-cause dementia (ACD) among 3,249 participants from the English Longitudinal Study of Ageing (ELSA) over a median 9.8-year follow-up, then validated in 1,506 incident ACD among 52,745 individuals from the UK Biobank (UKB) over median 13.7 years. NEFL and RPS6KB1 were robustly associated with incident ACD; MMP12 was associated with vascular dementia in ELSA. Additional markers EDA2R and KIM1 (HAVCR1) were identified from sensitivity analyses. Combining NEFL and RPS6KB1 with other factors yielded high predictive accuracy (area under the curve (AUC)=0.871) for incident ACD. Replication in the UKB confirmed associations between identified proteins with various dementia subtypes. Results from reverse Mendelian Randomization also supported the role of several proteins as early dementia biomarkers. These findings underscore proteomics’ potential in identifying novel risk screening targets for dementia.

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Section: Discussionmentioning

confidence: 99%

Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization

Gong,

Williams,

Scholes

et al. 2024

Preprint

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“…It has been known for many years that the changes following elastase application progress for many months following the initial insult [31,[35][36][37]. The positive feedback loop characterizing progressive emphysema includes mechanical forces, matrix metalloproteinases, proteolysis, thus resembling the pathophysiology of ageing in general [1,31,[38][39][40][41].…”

mentioning

confidence: 99%

“…However, we believe it to be unlikely that ARB elicits lung repair. Rather we assume that ARB interacts with mechanisms related to the evolution of emphysema following the initial event [31,35,38].…”

mentioning

confidence: 99%

Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model

Raupach

Lüthje

Kögler

et al. 2011

Pulmonary Pharmacology & Therapeutics

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions:The ARB irbesartan elicits encouraging beneficial effects on emphysema severity, lung biomechanics and exercise capacity in an emphysema mouse model. These findings might help to understand the corresponding positive effects of angiotensin II receptor blockade noticed in patients with COPD.

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“…(MMP-12) (113) and transforming growth factor β 1 (47) have also been reported in association with COPD.…”

Section: Risk Factors Of Copdmentioning

confidence: 99%

Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury

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A Functional MMP12 Polymorphism Is Associated with Lung Function throughout Life and Delayed Onset of COPD.

Cited by 5 publications

References 0 publications

Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization

Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization

Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model

Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury

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