A functional magnetic resonance imaging study of paced finger tapping in children

Rivkin, Michael J.; Vajapeyam, Sridhar; Hutton, Chloe; Weiler, Michael L; Hall, E.Kevin; Wolraich, David; Yoo, Seung Schik; Mulkern, Robert V.; Forbes, Peter; Wolff, Peter H.; Waber, Deborah P.

doi:10.1016/s0887-8994(02)00492-7

Cited by 33 publications

(25 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These authors also hypothesized a role for the pre-SMA (anterior to the perpendicular intersector of the line between the anterior and posterior commisures and passing through the anterior comissure) in directing internally generated sequences of finger movements not specified by external cues in children, since this was not observed in adults. Unlike Rivkin et al [13], midline motor activation was only found posterior (SMA) to the perpendicular intersector in this study. Overall, children showed greater activation than adults, with no regions showing greater activation during unpaced tapping in adults, even for a very relaxed threshold.…”

Section: Discussioncontrasting

confidence: 89%

“…Bilateral premotor activation has been reported in Rivkin et al [13] in a bimanual finger tapping study in children as well as anterodorsomedial cerebellum activation during self tapping that corresponds to the vermal activation found in this study. These authors also hypothesized a role for the pre-SMA (anterior to the perpendicular intersector of the line between the anterior and posterior commisures and passing through the anterior comissure) in directing internally generated sequences of finger movements not specified by external cues in children, since this was not observed in adults.…”

Section: Discussionsupporting

confidence: 86%

“…Midline cerebellar structures also project via thalamic nuclei [6,13] (children showed greater activity in the right thalamus) not only to motor and premotor cortex but also to SMA, prefrontal, posterior parietal and temporal regions [13], which is consistent with the greater activation observed in children in frontal and temporal regions in Table 3.…”

Section: Discussionsupporting

confidence: 60%

“…In adults, the premotor cortex has been shown to play an important role in the transformation of sensory information into appropriate motor behaviour especially in regards to sequential movements [32]. While premotor was definitely more active in children than in adults, we did not observe increased pre-SMA activation in the children during self-paced tapping as found by Rivkin et al [13], possibly because this task is motorically much less complex than the bimanual finger tapping task they used.…”

Section: Discussionsupporting

confidence: 57%

“…To our knowledge, only one fMRI study of finger tapping in healthy children has been reported [13]–a study that examined bimanual finger tapping. Because only children were assessed in that study, comparisons with adults were based on the published literature.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Functional Magnetic Resonance Imaging Study Comparing Rhythmic Finger Tapping in Children and Adults

Guio

Jacobson

Molteno

et al. 2012

Pediatric Neurology

View full text Add to dashboard Cite

This study compared brain activations during unpaced rhythmic finger tapping in 12-year old children with those of adults. The subject pressed a button at a pace initially indicated by a metronome (12 consecutive tones) and then continued for 16 seconds of unpaced tapping to provide an assessment of his/her ability to maintain a steady rhythm. In particular, the analyses focused on the superior vermis of the cerebellum, which is known to play a key role in timing. 12 adults and 12 children performed this rhythmic finger tapping task in a 3T scanner. Whole-brain analyses were performed in Brain Voyager with a random effects analysis of variance using the general linear model. A dedicated cerebellar atlas was used to localise cerebellar activations. As in adults, unpaced rhythmic finger tapping in children showed activations in the primary motor cortex, premotor cortex, and cerebellum. However, overall activation was different in that adults showed much more deactivation in response to the task, particularly in the occipital and frontal cortex. The other main differences were additional recruitment of motor and premotor areas in children compared to adults along with increased activity in the vermal region of the cerebellum. These findings suggest that the timing component of the unpaced rhythmic finger tapping task is less efficient and automatic in children, who needed to recruit the superior vermis more intensively to maintain the rhythm, even though they performed somewhat more poorly than the adults.

show abstract

Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 60%

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional Magnetic Resonance Imaging Study Comparing Rhythmic Finger Tapping in Children and Adults

Guio

Jacobson

Molteno

et al. 2012

Pediatric Neurology

View full text Add to dashboard Cite

show abstract

An fMRI study of finger tapping in children and adults

Turesky

Olulade

Luetje

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

Functional brain imaging studies have characterized the neural bases of voluntary movement for finger tapping in adults, but equivalent information for children is lacking. When contrasted to adults, one would expect children to have relatively greater activation, reflecting compensation for an underdeveloped motor system combined with less experience in the execution of voluntary movement. To test this hypothesis, we acquired functional magnetic resonance imaging (fMRI) data on 17 healthy right-handed children (7.48 ± 0.66 years) and 15 adults (24.9 ± 2.9 years) while they performed an irregularly paced finger-tapping task in response to a visual cue (left- and right-hand examined separately). Whole-brain within-group analyses revealed that finger tapping in either age group and for either hand activated contralateral SM1, SMA, ipsilateral anterior cerebellum, and occipital cortices. We used an ANOVA factorial design to test for main effects of Age Group (children vs adults), Hand (left vs. right), and their interactions. For main effects of Age Group, children showed relatively greater activity in left SM1 (extending into bilateral SMA), and, surprisingly, adults exhibited relatively greater activity in right pre-SMA/SMA (extending into left pre-SMA/SMA), right lateral globus pallidus, left putamen, and right anterior cerebellum. The interaction of Age Group × Hand revealed that while both groups activated right SM1 during left finger tapping and exhibited signal decreases (i.e., below fixation baseline) during right finger tapping, both these responses were attenuated in children relative to adults. These data provide an important foundation by which to study children with motor disorders.

show abstract

Current Awareness in NMR in Biomedicine

2003

NMR in Biomedicine

View full text Add to dashboard Cite

A functional magnetic resonance imaging study of paced finger tapping in children

Cited by 33 publications

References 44 publications

Functional Magnetic Resonance Imaging Study Comparing Rhythmic Finger Tapping in Children and Adults

Functional Magnetic Resonance Imaging Study Comparing Rhythmic Finger Tapping in Children and Adults

An fMRI study of finger tapping in children and adults

Current Awareness in NMR in Biomedicine

Contact Info

Product

Resources

About