A fully integrated, standalone stretchable device platform with in-sensor adaptive machine learning for rehabilitation

Abstract

Post-surgical treatments of the human throat often require continuous monitoring of diverse vital and muscle activities. However, wireless, continuous monitoring and analysis of these activities directly from the throat skin have not been developed. Here, we report the design and validation of a fully integrated standalone stretchable device platform that provides wireless measurements and machine learning-based analysis of diverse vibrations and muscle electrical activities from the throat. We demonstrate that the modified composite hydrogel with low contact impedance and reduced adhesion provides high-quality long-term monitoring of local muscle electrical signals. We show that the integrated triaxial broad-band accelerometer also measures large body movements and subtle physiological activities/vibrations. We find that the combined data processed by a 2D-like sequential feature extractor with fully connected neurons facilitates the classification of various motion/speech features at a high accuracy of over 90%, which adapts to the data with noise from motion artifacts or the data from new human subjects. The resulting standalone stretchable device with wireless monitoring and machine learning-based processing capabilities paves the way to design and apply wearable skin-interfaced systems for the remote monitoring and treatment evaluation of various diseases.

Fully Integrated Multiplexed Wristwatch for Real-Time Monitoring of Electrolyte Ions in Sweat

“…Regular calibration and maintenance are key to ensuring long-term stable operation of the sensors. Moreover, a self-adaptive in situ 3D printing method for living organ enhancement in robot-assisted healthcare, 55 low-cost printing of sensors and circuits on 3D freeform surfaces by intense pulsed light-induced mass transfer, 56 and an independent stretchable platform with machine learning-based processing capability to achieve motion artifact noise-free, 57 are all examples of technological advances that provide opportunities for personalized healthcare. These examples include innovative structural design, the development of high-stability sensing materials, the optimization of structural design, the improvement of production processes, and perfection of the integrated platform in multiple technical fields, all of which will provide highly flexible, efficient, stable, and low-cost sensing solutions for smart medical fields in the future.…”

Fully printed minimum port flexible interdigital electrode sensor arrays

“…The rapid development of flexible pressure sensors has led to a wide range of applications in fields such as electronic skin, [1][2][3][4] human-computer interaction, [5][6][7][8][9] and health monitoring. [10][11][12][13][14] Among various sensor designs, flexible sensors based on interdigital electrodes are a classic class that has attracted much attention. [15][16][17] However, flexible sensing arrays based on interdigital electrodes have always suffered from the problem of too many ports for electrical output.…”

A Laparoscopically Compatible Rapid‐Adhesion Bioadhesive for Asymmetric Adhesion, Non‐Pressing Hemostasis, and Seamless Seal

“…Recently, a growing number of smart bioadhesives with capabilities such as tissue adhesion, antimicrobial efficacy, real‐time sensing, wireless communication, and on‐demand therapeutic features, along with resulting self‐contained stretchable devices equipped with wireless monitoring and machine‐learning processing capabilities, have shown surprising promise in wound healing. [ 18,19 ] Bioadhesive hydrogels as a tissue adhesive, biocompatible, and biodegradable polymer that can adhere to internal tissues have gained great attention as a promising alternative in hemostatic agents, [ 20–27 ] physical barriers, [ 28,29 ] and wound healing. [ 30–35 ] By absorbing or removing interfacial water through press and forming covalent bonds with tissues to achieve strong adhesion with wet tissues instead of using sutures, hydrogels offer advantages over existing tissue adhesives and sealants.…”