A fully integrated graphene-polymer field-effect transistor biosensing device for on-site detection of glucose in human urine

Huang, Cong; Hao, Zhifeng; Wang, Z.; Zhao, Xuezeng; Wang, H.; Li, F.; Liu, S.; Pan, Yunlu

doi:10.1016/j.mtchem.2021.100635

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…However, reversible binding limits sensitivity and makes sub-pM detection challenging [ 160 ]. For sensors with strong analyte-receptor binding, the solvent environment can be altered to weaken the interaction to allow for dissociation and regeneration, with reagents such as acid buffers (pH = 2–4) [ 161 , 162 ] and detergents [ 163 ]. In particular, aptamers can be denatured with 6 M guanidinium chloride and refolded multiple times without loss of activity [ 164 , 165 ].…”

Section: Reusable Biofetsmentioning

confidence: 99%

Advances in field-effect biosensors towards point-of-use

Chen,

Bashir

2023

Nanotechnology

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The future of medical diagnostics calls for portable biosensors at the point of care, aiming to improve healthcare by reducing costs, improving access, and increasing quality – what is called the ‘triple aim’. Developing point-of-care sensors that provide high sensitivity, detect multiple analytes, and provide real time measurements can expand access to medical diagnostics for all. Field-effect transistor (FET)-based biosensors have several advantages, including ultrahigh sensitivity, label-free and amplification-free detection, reduced cost and complexity, portability, and large-scale multiplexing. They can also be integrated into wearable or implantable devices and provide continuous, real-time monitoring of analytes in vivo, enabling early detection of biomarkers for disease diagnosis and management. This review analyzes advances in the sensitivity, parallelization, and reusability of FET biosensors, benchmarks the limit of detection of the state of the art, and discusses challenges and opportunities towards ultrasensitive, parallelized, and reusable FET biosensors for future healthcare applications.

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Section: Reusable Biofetsmentioning

confidence: 99%

Advances in field-effect biosensors towards point-of-use

Chen,

Bashir

2023

Nanotechnology

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“…Huang et al [ 31 ] recently reported glucose biosensors with high sensitivity and selectivity using a polymer and graphene without an enzyme. The biosensor was functionalized with a poly (acrylamide (Aam)-3-acrylamidophenylboronic acid (AAPBA)-N-dimethylaminopropyl acrylamide (DMAAPA)) for glucose, allowing the covalent bonding of AAPBA to its surface via chemisorption.…”

Section: Detecting Analytes In Urine For Urinalysismentioning

confidence: 99%

Recent Advances in Biosensor Technologies for Point-of-Care Urinalysis

et al. 2022

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Human urine samples are non-invasive, readily available, and contain several components that can provide useful indicators of the health status of patients. Hence, urine is a desirable and important template to aid in the diagnosis of common clinical conditions. Conventional methods such as dipstick tests, urine culture, and urine microscopy are commonly used for urinalysis. Among them, the dipstick test is undoubtedly the most popular owing to its ease of use, low cost, and quick response. Despite these advantages, the dipstick test has limitations in terms of sensitivity, selectivity, reusability, and quantitative evaluation of diseases. Various biosensor technologies give it the potential for being developed into point-of-care (POC) applications by overcoming these limitations of the dipstick test. Here, we present a review of the biosensor technologies available to identify urine-based biomarkers that are typically detected by the dipstick test and discuss the present limitations and challenges that future development for their translation into POC applications for urinalysis.

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“…ii) A labeled receptor into the sensing surface is required to provide specificity [ [27] , [28] , [29] ]. iii) The easy-to-integrate process of the electronic measurement setup for FET-based sensors within a small-sized device for portable applications [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%