A fully ingrowing implant for cranial reconstruction: Results in critical size defects in sheep using 3D-printed titanium scaffold

Hubbe, Ulrich; Beiser, Svea; Kuhn, Sofia Aumond; Stark, T.; Cristina-Schmitz, Heidi; Vasilikos, Ioannis; Metzger, Marc Christian; Rothweiler, René

doi:10.1016/j.bioadv.2022.212754

Cited by 12 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apatite also occurs in nature [ 163 , 164 , 165 ], sometimes as inclusions in gems [ 166 ] or in association with other minerals [ 167 , 168 ]. As a biomaterial, it has very good properties [ 169 ], and it is hoped that in combination with metal implants, it will be able to increase the biointegration of the latter [ 170 ]. The potential of hydroxyapatite as a biomaterial is indeed immense [ 24 ] and is associated with its capacity to promote cellular integration and responsiveness [ 171 ].…”

Section: Biomaterials Compatible With Antibiotic Infusionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

View full text Add to dashboard Cite

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

show abstract

Section: Biomaterials Compatible With Antibiotic Infusionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

View full text Add to dashboard Cite

show abstract

“…Hap 3Dprinted constructs have excellent bioactive properties, including increased biocompatibility, osteoinductivity, osteoconductivity, excellent bioresorbability and biodegradation, and near-to-zero cytotoxicity [49][50][51][52][53]. These qualities hold significant importance in medical applications such as tissue engineering for bone grafts [49][50][51]53], dental root implants [52], and coatings for 3D-printed metallic implants [54][55][56].…”

Section: Biomaterials Adapted To Vpp 3d Printingmentioning

confidence: 99%

“…Despite not being printed via VPP, hydroxyapatite coatings are representative of the compound's bioactive properties [54]. As most orthopedic implants are composed of biocompatible metals such as titanium due to their superior biomechanical properties [60], there are still some challenges with the biointegration of the implants, which can be effectively addressed through Hap coatings or Hap-ion coatings [55].…”

Section: Biomaterials Adapted To Vpp 3d Printingmentioning

confidence: 99%

Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

Timofticiuc,

Călinescu,

Iftime

et al. 2023

JFB

View full text Add to dashboard Cite

Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality. Instead of developing completely new materials, an alternate approach to solving this problem involves adapting existing biomaterials. These materials are incompatible with VPP 3D printing in their pure form but can be adapted to the VPP chemistry and general process through the use of innovative mixtures and the addition of specific pre- and post-printing steps. This review’s primary objective is to highlight biofunctional and biocompatible materials that have been adapted to VPP. We present and compare the suitability of these adapted materials to different medical applications and propose other biomaterials that could be further adapted to the VPP 3D printing process in order to fulfill patient-specific medical requirements.

show abstract

“…Recently, an idea appeared to fill bone defects with a personalized titanium implants, the design of which (inner cells and pores) is similar to the structure of spongy bone [ 10 , 11 , 12 ]. Experimental studies demonstrated that osseointegration of such an implant provides fast and durable restoration of a bone defect, but the titanium does not allow monitoring the process of reparative bone regeneration and its functional restructuring in clinical conditions by the methods of X-rays [ 13 , 14 , 15 ]. Furthermore, sometimes a metal implant remained into the bone arises concerns of a patient.…”

Section: Introductionmentioning

confidence: 99%

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

et al. 2023

View full text Add to dashboard Cite

Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone regeneration from the periosteum lying on the periphery of cylindrical implant to its center in a week after the surgery. Cellular structure of the implant was fully filled with newly-formed bone tissue on the 4th week after the surgery. The bone tissue regeneration from the proximal and distal bone fragments was evident on 3rd week. This provides insight into the use of bioactive degradable implants for the restoration of segmental bone defects. Degradable implant with bioactive coating implanted into a long bone segmental defect provides stimulation of reparative osteogenesis and osseointegration into the single implant-bone block.

show abstract

A fully ingrowing implant for cranial reconstruction: Results in critical size defects in sheep using 3D-printed titanium scaffold

Cited by 12 publications

References 38 publications

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Contact Info

Product

Resources

About