A frontier-orbital view of the initial steps of lytic polysaccharide monooxygenase reactions
Erna Katharina Wieduwilt,
Leila Lo Leggio,
Erik Donovan Hedegård
Abstract:Lytic polysaccharide monooxygenases (LPMOs) are copper enzymes that oxidatively cleave the strong C-H bonds in recalcitrant polysaccharides, thereby playing a crucial role in biomass degradation. Recently, LPMOs have also been shown to be important for several pathogens. It is well established that the Cu(II) resting state of LPMOs is inactive, and the electronic structure of the active site needs to be altered to transform the enzyme into an active form. Whether this transformation occurs due to substrate bin… Show more
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