A FRET-based aptasensor for the detection of α-synuclein oligomers as biomarkers of Parkinson's disease

Abstract

Soluble oligomers of ɑ-synuclein (ɑ-syn) are known to be responsible for neuronal death in early stages of Parkinson’s disease (PD). Thus, the development of a simple, rapid, and inexpensive method...

Advances in graphene-based nanoplatforms and their application in Parkinson's disease

“…Significantly, FAM-labeled aptamer on the GO nanosheet specifically detected a-syn oligomers with a LOD of 6.3 nM, and it exhibited a good analytical performance in spiked human saliva samples. 85 Graphene also offers a promising application in bioelectrical studies. Guo et al presented a graphene biosensor to sense electrical signaling in N27 cells, which can be used for monitoring cell electrophysiology due to good biocompatibility.…”

Construction and bioanalytical applications of poly-adenine-mediated gold nanoparticle-based spherical nucleic acids

“…Abnormal or unique protein expression is oen associated with certain disease. [100][101][102][103] For instance, the concentration of prostate specic antigen (PSA) in the blood, which is secreted by prostate epithelial cells, increases as prostate cancer progresses. 104 The high expression of a transmembrane glycoprotein called the epithelial cell adhesion molecule is associated with metastases, malignant effusions, and cancer stem cells.…”

An innovative method for the detection of alpha synuclein, a potential biomarker of Parkinson's disease: quartz tuning fork-based mass sensitive immunosensor design

“…15 In recent years, developments in portable biosensor technologies offer opportunities for on-site analysis of disease biomarkers from various body fluids and even interpretation of the course of the disease treatment plan, without the need for invasive procedures. Liquid crystal-based, 16,17 electrochemical-based (can be amperometric, potentiometric or impedimetric), [18][19][20][21] photoelectrochemical-based, 22,23 Fo ¨rster resonance energy transfer-based 24,25 studies come to the fore in biosensor systems developed for Syn alpha detection. These biosensor systems offer very different results in analytical characteristics such as selectivity, sensitivity, repeatability and stability.…”