A fresh look at adult neurogenesis

Steiner, Embla; Tata, Mathew; Frisén, Jonas

doi:10.1038/s41591-019-0408-4

Cited by 18 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the post‐natal stages in mammals, the majority of the astroglia are non‐neurogenic although they divide, expand and populate almost the entire central nervous system (Burns, Murphy, Danzer, & Kuan, 2009; Gotz, Sirko, Beckers, & Irmler, 2015; Heins et al, 2002). Yet, some astrocytes are set aside in specific regions of the brain and continue to be neurogenic progenitors throughout life (Doetsch, Garcia‐Verdugo, & Alvarez‐Buylla, 1997; Goldman & Nottebohm, 1983; Kempermann, van Praag, & Gage, 2000; Steiner, Tata, & Frisen, 2019). Two such regions that are highly studied are located in the forebrain (telencephalon) and are called neural stem cell niches of the subventricular zone (SVZ) of the lateral ventricle and in the dentate gyrus of the hippocampus (Doetsch, 2003a, 2003b; Doetsch, Caille, Lim, Garcia‐Verdugo, & Alvarez‐Buylla, 1999; Doetsch & Scharff, 2001; Morrens, Van Den Broeck, & Kempermann, 2012; Urban & Guillemot, 2014).…”

Section: Neurogenesis and Neural Regeneration From Gliamentioning

confidence: 99%

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Jurisch‐Yaksi

Yaksi

Kızıl

2020

Glia

121

107

View full text Add to dashboard Cite

The neuroscience community has witnessed a tremendous expansion of glia research. Glial cells are now on center stage with leading roles in the development, maturation, and physiology of brain circuits. Over the course of evolution, glia have highly diversified and include the radial glia, astroglia or astrocytes, microglia, oligodendrocytes, and ependymal cells, each having dedicated functions in the brain. The zebrafish, a small teleost fish, is no exception to this and recent evidences point to evolutionarily conserved roles for glia in the development and physiology of its nervous system. Due to its small size, transparency, and genetic amenability, the zebrafish has become an increasingly prominent animal model for brain research. It has enabled the study of neural circuits from individual cells to entire brains, with a precision unmatched in other vertebrate models. Moreover, its high neurogenic and regenerative potential has attracted a lot of attention from the research community focusing on neural stem cells and neurodegenerative diseases. Hence, studies using zebrafish have the potential to provide fundamental insights about brain development and function, and also elucidate neural and molecular mechanisms of neurological diseases. We will discuss here recent discoveries on the diverse roles of radial glia and astroglia in neurogenesis, in modulating neuronal activity and in regulating brain homeostasis at the brain barriers. By comparing insights made in various animal models, particularly mammals and zebrafish, our goal is to highlight the similarities and differences in glia biology among species, which could set new paradigms relevant to humans.

show abstract

Section: Neurogenesis and Neural Regeneration From Gliamentioning

confidence: 99%

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Jurisch‐Yaksi

Yaksi

Kızıl

2020

Glia

121

107

View full text Add to dashboard Cite

show abstract

“…Literature on anti-inflammatory, anti-oxidative and anti-apoptotic effects of irisin in various pathological conditions such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, chronic liver disease, osteoporosis, hypertension, atherosclerosis, Alzheimer, and cancer, shows promising results [10][11][12][13][14][15][16][17][18]. Physical inactivity and increased abdominal adiposity are associated with persistent systemic low-grade inflammation [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cosio

Crespo-Posadas

Velarde-Sotres

et al. 2021

IJERPH

View full text Add to dashboard Cite

Irisin seems to play an important role in several chronic diseases, however, the interactions between chronic training and irisin are still unclear. The purpose of this systematic review and meta-analysis was to examine the effect of chronic resistance training on circulating irisin in adults. Literature search was conducted in PubMed, Web of Science and EBSCOhost (Academic Search Complete) until December 2020. Randomized controlled trials researching irisin levels after a resistance training program for at least 8 weeks among an adult population were eligible. Other inclusion criteria comprised recruiting a control group and reporting circulating irisin through ELISA kits. Cohen’s d effect size and subgroup analyses (95% confidence level) were calculated using a random effects analysis model. Data of the seven included studies comprising 282 individuals showed an increasing and non-significant tendency after a resistance training program (d = 0.58, 95% CI: −0.25 to 1.40, p = 0.17). Subgroup analyses showed significant increases for the older adults group (p < 0.001) and when training is demanding and progressive in terms of intensity (p = 0.03). Data suggest that resistance training programs seem to increase circulating irisin, especially in older adults and in demanding and progressive training programs. However, more studies should be conducted using robust measurement methods, such as mass spectrometry, to better understand the interaction between chronic resistance exercise and irisin.

show abstract

“…30 Some studies have established a co-relation between dysregulated adult hippocampal neurogenesis and mental illness such as anxiety, depression etc. 31,32 But these experiments are focused on rodent models and as a result, they don't necessarily give a clear picture of the scenario in humans.…”

Section: Neurogenesis In the Adult Brainmentioning

confidence: 99%

Association of adult hippocampal neurogenesis with alzheimer’s disease

Gope

2020

Int J Community Med Public Health

View full text Add to dashboard Cite

Neurogenesis in the adult brain has been reported to occur within three distinct regions, of which Hippocampus is the most studied one because of its importance in cognition and memory. Alzheimer’s disease attributes to almost 62% of all dementia cases. A recent study has established a link between adult hippocampal neurogenesis and alzheimer’s disease wherein a sharp decline in AHN is observed in patients suffering from alzheimer’s. This review summarizes alzheimer’s disease, the decline in AHN in alzheimer’s patients and probes into the efficacy of the newly generated hippocampal neurons in the context of memory and cognition. It also discusses the potential of targeting reduced AHN in alzheimer’s patients using neural stem cell-based therapy.

show abstract

A fresh look at adult neurogenesis

Cited by 18 publications

References 10 publications

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Association of adult hippocampal neurogenesis with alzheimer’s disease

Contact Info

Product

Resources

About