A French single-center experience on allogeneic stem cell transplant cryopreservation during severe acute respiratory syndrome coronavirus 2 pandemic

Pros and Cons of Cryopreserving Allogeneic Stem Cell Products

“…In total, 1739 references were identified on 15 January 2024. In the end, 29 papers were included [ 54 , 55 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 ] ( Figure 1 ).…”

“…Similar findings were reported by Guo et al in a single center study involving 34 patients receiving cryopreserved PBSC transplant and 31 controls [ 101 ]. Conversely, various single-institution studies found no differences between cryo- and fresh grafts in unrelated donor transplants [ 102 , 103 , 104 , 105 , 106 ]. A further single institution study reported delayed engraftment and a trend toward poorer immuno-reconstitution of cryopreserved allografts overall in myeloablative conditioning transplant [ 107 ].…”

“… Days to neutrophil and platelet recovery [ 86 , 88 , 89 , 91 , 92 , 93 , 94 , 95 , 96 , 98 , 99 , 101 , 102 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 ]. Data are given as median and range, median and 95% confidence interval a , or median and interquartile range b .…”