A French Case of Laboratory-Acquired Disseminated Penicillium marneffei Infection in a Patient with AIDS

Hilmarsdóttir, I.; Coutellier, A; Elbaz, Jocelyne; Klein, Jean Marie; Datry, A.; Guého, E.; Herson, S.

doi:10.1093/clinids/19.2.357

Cited by 40 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of infections by P. marneffei were diagnosed in AIDS patients in Thailand; however, infections were also observed in Cambodia (4), China (101), Hong Kong (20,85,164,166,185), India (125), Malaysia (132), Taiwan (21,25,64,66,103), and Vietnam (61,67). Cases from outside the region of endemicity were observed in HIV-infected patients from Australia (60,75), Belgium (35), France (54,62,63,169), Germany (129,147), Japan (113,167), Sweden (77), Switzerland (10,52,88), The Netherlands (65,87), the United Kingdom (6,111,119,178), and the United States (114). Currently, the prevalence of human penicilliosis marneffei infection is increasing in areas where HIV infection is on the increase, for instance, Vietnam (67).…”

Section: Discovery Of P Marneffei and P Marneffei Infectionmentioning

confidence: 99%

Penicillium marneffeiInfection and Recent Advances in the Epidemiology and Molecular Biology Aspects

et al. 2006

View full text Add to dashboard Cite

SUMMARY Penicillium marneffei infection is an important emerging public health problem, especially among patients infected with human immunodeficiency virus in the areas of endemicity in southeast Asia, India, and China. Within these regions, P. marneffei infection is regarded as an AIDS-defining illness, and the severity of the disease depends on the immunological status of the infected individual. Early diagnosis by serologic and molecular assay-based methods have been developed and are proving to be important in diagnosing infection. The occurrence of natural reservoirs and the molecular epidemiology of P. marneffei have been studied; however, the natural history and mode of transmission of the organism remain unclear. Soil exposure, especially during the rainy season, has been suggested to be a critical risk factor. Using a highly discriminatory molecular technique, multilocus microsatellite typing, to characterize this fungus, several isolates from bamboo rats and humans were shown to share identical multilocus genotypes. These data suggest either that transmission of P. marneffei may occur from rodents to humans or that rodents and humans are coinfected from common environmental sources. These putative natural cycles of P. marneffei infection need further investigation. Studies on the fungal genetics of P. marneffei have been focused on the characterization of genetic determinants that may play important roles in asexual development, mycelial-to-yeast phase transition, and the expression of antigenic determinants. Molecular studies have identified several genes involved in germination, hyphal development, conidiogenesis, and yeast cell polarity. A number of functionally important genes, such as the malate synthase- and catalase-peroxidase protein-encoding genes, have been identified as being upregulated in the yeast phase. Future investigations pertaining to the roles of these genes in host-fungus interactions may provide the key knowledge to understanding the pathogenicity of P. marneffei.

show abstract

Section: Discovery Of P Marneffei and P Marneffei Infectionmentioning

confidence: 99%

Penicillium marneffeiInfection and Recent Advances in the Epidemiology and Molecular Biology Aspects

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Another laboratory-acquired infection was reported in an undiagnosed HIV-positive physician who visited a laboratory where students were handling P. marneffei cultures on the open bench. He developed disseminated infection shortly after the exposure and the presumptive route of acquisition was inhalation [32]. The CDC has recommended Biosafety Level-2 (BSL-2) practices with containment equipment and facilities for propagating and manipulating P. marneffei cultures [33].…”

Section: Epidemiologymentioning

confidence: 99%

Penicillium marneffeiInfection in AIDS

Wong

2011

Pathology Research International

View full text Add to dashboard Cite

Penicillium marneffei is a dimorphic fungus which is endemic in Southeast Asia. It is an opportunistic pathogen which has emerged to become an AIDS-defining illness in the endemic areas. Early diagnosis with prompt initiation of treatment is crucial for its management. Prompt diagnosis can often be established through careful cytological and histological examination of clinical specimens although microbiological culture remains the gold standard for its diagnosis. Standard antifungal treatment for AIDS patients with penicilliosis is well established. Highly active antiretroviral therapy should be started early together with the antifungal treatment. Special attention should be paid to potential drug interaction between antiretroviral and antifungal treatments. Secondary prophylaxis may be discontinued with a low risk of relapse of the infection once the immune dysfunction has improved.

show abstract

“…No definitive mode of acquisition has been found, but inhalation has been implicated [2,3]. The infection has been described in both immunocompromised (180%) and immunocompetent individuals [4].…”

Section: Penicillium Marneffei Is An Important Human Immunodeficiencymentioning

confidence: 99%

AIDS‐AssociatedPenicillium marneffeiInfection of the Central Nervous System

Huu

Cuc

et al. 2010

CLIN INFECT DIS

View full text Add to dashboard Cite

Penicillium marneffei is an important human immunodeficiency virus-associated opportunistic infection endemic in Southeast Asia. Central nervous system infection has not been described. We report the first case series of 21 human immunodeficiency virus-infected patients who presented with a syndrome consistent with acute central nervous system infection and who had Penicillium marneffei isolated from cerebrospinal fluid.

show abstract

A French Case of Laboratory-Acquired Disseminated Penicillium marneffei Infection in a Patient with AIDS

Cited by 40 publications

References 0 publications

Penicillium marneffeiInfection and Recent Advances in the Epidemiology and Molecular Biology Aspects

Penicillium marneffeiInfection and Recent Advances in the Epidemiology and Molecular Biology Aspects

Penicillium marneffeiInfection in AIDS

AIDS‐AssociatedPenicillium marneffeiInfection of the Central Nervous System

Contact Info

Product

Resources

About