A framework for the analysis of mixed time series/point process data—Theory and application to the study of physiological tremor, single motor unit discharges and electromyograms

Halliday, David M.; Rosenberg, J.R.; Amjad, A.M.; Breeze, Peter; Conway, B.A.; Farmer, Simon F.

doi:10.1016/s0079-6107(96)00009-0

Cited by 993 publications

(1,001 citation statements)

References 14 publications

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“…Power spectra were generated from the 150 s epochs associated with each dose of FG-7142, using periodogram-based spectral estimation techniques (Halliday et al, 1995). Power spectra were also generated in response to administration of vehicle, FLU and FG-7142 in the antagonist pretreatment experiment.…”

Section: Lfp Activitymentioning

confidence: 99%

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

Synapse

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The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) coordinate various stress responses. Although the effects of stressors on mPFC and BLA activity have been previously examined, it remains unclear to what extent stressors affect functional interactions between these regions. In vivo electrophysiology in the anesthetized rat was used to examine mPFC and BLA activity simultaneously in response to FG-7142, a benzodiazepine receptor partial inverse agonist that mimics various stress responses, in an attempt to model the effects of stressors on corticolimbic functional connectivity. Extracellular unit and local field potential (LFP) recordings, using multielectrode arrays positioned in mPFC and BLA, were conducted under basal conditions and in response to systemic FG-7142 administration. This drug increased mPFC and BLA unit firing at the lowest dose tested, whereas higher doses of FG-7142 decreased various burst firing parameters in both regions. Moreover, LFP power was attenuated at lower (<1 Hz) and potentiated at higher frequencies in mPFC (1-12 Hz) and BLA (4-8 Hz). Interestingly, FG-7142 diminished synchronized unit firing, both within and between mPFC and BLA. Finally, FG-7142 decreased LFP synchronization between these regions. In a separate group of animals, pretreatment with the selective benzodiazepine receptor antagonist flumazenil blocked the changes in burst firing, LFP power and synchronized activity induced by FG-7142, confirming direct benzodiazepine receptor-mediated effects. These results indicate that FG-7142 disrupts corticolimbic network interactions via benzodiazepine receptor partial inverse agonism. Perturbation of mPFC-BLA functional connectivity induced by FG-7142 may provide a useful model of corticolimbic dysfunction induced by stressors.

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Section: Lfp Activitymentioning

confidence: 99%

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

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“…Coherence analysis was performed using in‐house written software build in LabVIEW (National Instruments 2014, Austin, Texas, United States) based on the description of Halliday and colleagues (1995) 23. The same EEG‐EMG filter and re‐referencing method used for JLBA were applied.…”

Section: Methodsmentioning

confidence: 99%

“…Coherence (range 0–1) was calculated and considered significant if exceeding the 95% confidence level at four or more consecutive 1 Hz bins. Phase lag and corticomuscular conduction time were assessed for the significant coherence bins 23, 31. CM was considered present (coherence positive) if coherence was found between motor cortex and contralateral myoclonus muscle with appropriate phase (EMG follows EEG) and conduction time 23.…”

Section: Methodsmentioning

confidence: 99%

“…Phase lag and corticomuscular conduction time were assessed for the significant coherence bins 23, 31. CM was considered present (coherence positive) if coherence was found between motor cortex and contralateral myoclonus muscle with appropriate phase (EMG follows EEG) and conduction time 23. SM was concluded (coherence negative) if no corticomuscular coherence, or corticomuscular coherence with inappropriate phase (EEG follows EMG) was present (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…A strictly downstream (i.e., cranio‐caudal) muscle recruitment pattern is more likely to originate from the cortex 11. Finally, a combined EEG‐EMG approach permits identifying the origin of myoclonus by Jerk‐Locked Back Averaging (JLBA) and coherence analysis 11, 18, 20, 21, 22, 23…”

Section: Introductionmentioning

confidence: 99%

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The interrelation between clinical presentation and neurophysiology of posthypoxic myoclonus

Zijl

Beudel

Jong

et al. 2018

Ann Clin Transl Neurol

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ObjectivePosthypoxic myoclonus (PHM) in the first few days after resuscitation can be divided clinically into generalized and focal (uni‐ and multifocal) subtypes. The former is associated with a subcortical origin and poor prognosis in patients with postanoxic encephalopathy (PAE), and the latter with a cortical origin and better prognosis. However, use of PHM as prognosticator in PAE is hampered by the modest objectivity in its clinical assessment. Therefore, we aimed to obtain the anatomical origin of PHM with use of neurophysiological investigations, and relate these to its clinical presentation.MethodsThis study included 20 patients (56 ± 18 y/o, 68% M, 2 survived, 1 excluded) with EEG‐EMG‐video recording. Three neurologists classified PHM into generalized or focal PHM. Anatomical origin (cortical/subcortical) was assessed with basic and advanced neurophysiology (Jerk‐Locked Back Averaging, coherence analysis).ResultsClinically assessed origin of PHM did not match the result obtained with neurophysiology: cortical PHM was more likely present in generalized than in focal PHM. In addition, some cases demonstrated co‐occurrence of cortical and subcortical myoclonus. Patients that recovered from PAE had cortical myoclonus (1 generalized, 1 focal).InterpretationHypoxic damage to variable cortical and subcortical areas in the brain may lead to mixed and varying clinical manifestations of myoclonus that differ of those patients with myoclonus generally encountered in the outpatient clinic. The current clinical classification of PHM is not adequately refined to play a pivotal role in guiding treatment decisions to withdraw care. Our neurophysiological characterization of PHM provides specific parameters to be used in designing future comprehensive studies addressing the potential role of PHM as prognosticator in PAE.

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Single‐Channel Techniques for Information Extraction from the Surface EMG Signal

Clancy

Negro

Farina³

2004

Electromyography

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A framework for the analysis of mixed time series/point process data—Theory and application to the study of physiological tremor, single motor unit discharges and electromyograms

Cited by 993 publications

References 14 publications

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

The interrelation between clinical presentation and neurophysiology of posthypoxic myoclonus

Single‐Channel Techniques for Information Extraction from the Surface EMG Signal

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