A framework for systematic crystal shape tuning – Case of Lovastatin's needle-shaped crystals

Li, Wei; Hatcher, Lauren E.; Wilson, Chick C.; Rielly, Chris D.; Benyahia, Brahim

doi:10.1016/j.cherd.2023.12.016

Cited by 1 publication

(1 citation statement)

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“…Direct nucleation control (DNC) is a feedback control technology predicated on the number of crystals, in which the nucleation rate was controlled directly according to the FBRM measurement of the addition of the antisolvent or the cooling rate, thus responding immediately to any unexpected interference. , DNC can precisely regulate the nucleation rate during the crystallization process, aiming to optimize crystal characteristics , and enhance overall production efficiency Figure shows a schematic diagram of the DNC method for cooling crystallization systems, wherein the regulation of count quantities within the system is controlled by an adaptive heating/cooling cycle.…”

Section: Assisted Nucleation Controlmentioning

confidence: 99%

Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization

Zhang,

Meng,

Long

et al. 2024

Org. Process Res. Dev.

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Nucleation as a unique phenomenon in the crystallization process has always been a hot topic. With the development of nucleation theory and process analysis technology (PAT), nucleation control technology (NCT) has been widely applied in industrial crystallization processes. This paper provides a comprehensive review of advancements in nucleation measurement and control technologies within crystallization processes, systematically analyzing the principles, advantages, disadvantages, and application scopes of various NCTs, and particularly the factors affecting nucleation and nucleation-assisted technologies, including ultrasound, gassing, and membranes, are elaborated. These technologies are crucial for managing the unpredictable nature of nucleation to improve the consistency and quality of crystalline products. These advanced or novel control technologies are very attractive in providing continuous and stable high-purity seeds without externally adding additional seeds and have proven to be effective alternative methods for generating internal seeds. In addition, the challenges and opportunities were pointed out from the stability, controllability, and consistency of nucleation to promoting the efficient development of crystallization technology. NCTs play a vital role in industrial applications by ensuring control over the size, purity, and morphology of crystals. This review also explains the application of NCTs in industrial scenarios, positioning these technologies as essential for the advancement of various industrial applications.

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