Industrialized societies depend on the proper functioning of a whole range of technological infrastructures, such as electricity, road and railway networks and telecommunications which, due to their importance, are generically referred to as critical infrastructures (CIs). Technical failures, natural disasters and malicious events, if not terrorist, could have devastating effects on these infrastructures. The events of the last few years have accelerated efforts to identify and designate CIs at national and European levels and have reinforced concerns about increasing their protection in sensitive sectors for the safety of the individual and the community. The aim of this research is to provide the basic elements to understand the issue along with the reasons for its importance both at national, European and international level. In particular, after analyzing the origin of the problem, a systematic literature review is carried out to study the current research around future perspectives relating to the management of Cis, with particular focus on three research questions: RQ1 “What types of risk assessment methods are used to manage CIs?”, RQ2 “What are the environmental risk mitigation strategies for CIs?” and RQ3 “What is the role of the human factor in the prevention of risks for CIs?”. The results aim to be guidelines for decision makers and researchers interested in this topic.