A framework for global surveillance of antibiotic resistance

Grundmann, Hajo; Klugman, Keith P.; Walsh, Timothy R.; Ramón-Pardo, Pilar; Sigaùque, Betuel; Khan, Wasif Ali; Laxminarayan, Ramanan; Heddini, Andreas; Stelling, John

doi:10.1016/j.drup.2011.02.007

Cited by 106 publications

(77 citation statements)

References 21 publications

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“…Even though Adam et al in a study done among Canadian hospitals reported that resistance was encroaching to these drug classes, the resistance rate shown in this study is far higher compared to the findings of Adam et al This is a significant finding denoting that geographical location does play a role in development of antimicrobial resistance, and therefore might mean that due to rapid increase and high level of intercontinental mobility, such as global air travel, resistant clones are bound to rapidly disseminate across different countries and regions [4,21,30,31].…”

Section: Discussioncontrasting

confidence: 44%

Laboratory information system for reporting antimicrobial resistant isolates from academic hospitals, South Africa

Nyasulu

Murray

Perovic

et al. 2017

J Infect Dev Ctries

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Introduction: We aimed to evaluate the appropriateness of Digital Innovation South Africa (DISA)-based laboratory information system (LIS) for assessing the prevalence, patterns and trends of antimicrobial resistance, and associated demographic factors. Methodology: A retrospective analysis was conducted on routine data of blood culture isolates of Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. These isolates were collected by the National Health Laboratory Services between July 1, 2005 and December 31, 2009 at seven tertiary public hospitals. Factors associated with antimicrobial resistance were analysed using multivariate logistic regression. Results: Information on 9969 isolates was available, of which 3942 (39.5%), 4466 (44.8%) and 1561 (15.7%) were Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa, respectively. Reporting of resistance across antibiotics tested was highest in patient age group less than 5 years old. Methicillin resistant Staphylococcus aureus was 39% on average. There was a significant increasing trend of Klebsiella pneumoniae resistance to ciprofloxacin (32.6% to 64.9%, p < 0.001), cotrimoxazole (67.5% to 81.6%, p < 0.001) and cefotaximeceftriaxone (55.5% to 73.2%, p < 0.001) over the study period. Pseudomonas aeruginosa resistance to meropenem showed a significant increasing trend from 2006 (27.5%) to 2009 (53.9%) (p < 0.001). Age group < 5 years, female gender, hospital location, year of infection were significantly associated with antimicrobial resistance. Conclusions: The percentages of antimicrobial resistance were high and showed a significant increasing trend among individual agents over the duration of the study e.g. ciprofloxacin, cotrimoxazole among others. Continued surveillance of antimicrobial resistance among bloodstream hospital-acquired infections should be strengthened.

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Section: Discussioncontrasting

confidence: 44%

Laboratory information system for reporting antimicrobial resistant isolates from academic hospitals, South Africa

Nyasulu

Murray

Perovic

et al. 2017

J Infect Dev Ctries

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“…An effective pharmacovigilance, however, is expensive and complicated that make it not a priority for those countries, thus the surveillance and monitoring system became weak or absent. This causes a lack of collaborative global surveillance for antibiotic resistance, thus, inhibiting efforts to identify, characterize, and contain new threats; and to systematically compare and evaluate the value of national resistance containment activities [24].…”

mentioning

confidence: 99%

Antibiotic Abuse in Developing Countries

Abdulah¹

2012

Pharmaceut Reg Affairs

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“…187 The OIE has determined that 111 (73%) of 178 member countries have no official system for collecting data on antimicrobial use in animals. In Africa and the Americas this percentage rises to 95% and 96% of countries respectively.…”

Section: Surveillance In Animals and The Environmentmentioning

confidence: 99%