A framework for breast cancer classification using Multi-DCNNs

Ragab, Dina A.; Attallah, Omneya; Sharkas, Maha; Ren, Jinchang; Marshall, Stephen

doi:10.1016/j.compbiomed.2021.104245

Cited by 108 publications

(39 citation statements)

References 69 publications

(91 reference statements)

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“…Rakhlin et al [ 49 ] applied the fusion methods of different DCNN algorithms to determine the sensitivity, AUC for two classes of breast cancer. Ragab et al [ 50 ] presented a novel CAD system based on feature extraction and classification leveraging DL methods to aid radiologists in classifying breast cancer anomalies in mammography. DCNNs were used to extract deep features, which were used to train and evaluate a support vector machine classifier using various kernel functions in the second experiment.…”

Section: Experimental Work Setupmentioning

confidence: 99%

An Automated In-Depth Feature Learning Algorithm for Breast Abnormality Prognosis and Robust Characterization from Mammography Images Using Deep Transfer Learning

Mahmood

Pei

et al. 2021

Biology

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Background: Diagnosing breast cancer masses and calcification clusters have paramount significance in mammography, which aids in mitigating the disease’s complexities and curing it at early stages. However, a wrong mammogram interpretation may lead to an unnecessary biopsy of the false-positive findings, which reduces the patient’s survival chances. Consequently, approaches that learn to discern breast masses can reduce the number of misconceptions and incorrect diagnoses. Conventionally used classification models focus on feature extraction techniques specific to a particular problem based on domain information. Deep learning strategies are becoming promising alternatives to solve the many challenges of feature-based approaches. Methods: This study introduces a convolutional neural network (ConvNet)-based deep learning method to extract features at varying densities and discern mammography’s normal and suspected regions. Two different experiments were carried out to make an accurate diagnosis and classification. The first experiment consisted of five end-to-end pre-trained and fine-tuned deep convolution neural networks (DCNN). The in-depth features extracted from the ConvNet are also used to train the support vector machine algorithm to achieve excellent performance in the second experiment. Additionally, DCNN is the most frequently used image interpretation and classification method, including VGGNet, GoogLeNet, MobileNet, ResNet, and DenseNet. Moreover, this study pertains to data cleaning, preprocessing, and data augmentation, and improving mass recognition accuracy. The efficacy of all models is evaluated by training and testing three mammography datasets and has exhibited remarkable results. Results: Our deep learning ConvNet+SVM model obtained a discriminative training accuracy of 97.7% and validating accuracy of 97.8%, contrary to this, VGGNet16 method yielded 90.2%, 93.5% for VGGNet19, 63.4% for GoogLeNet, 82.9% for MobileNetV2, 75.1% for ResNet50, and 72.9% for DenseNet121. Conclusions: The proposed model’s improvement and validation are appropriated in conventional pathological practices that conceivably reduce the pathologist’s strain in predicting clinical outcomes by analyzing patients’ mammography images.

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Section: Experimental Work Setupmentioning

confidence: 99%

An Automated In-Depth Feature Learning Algorithm for Breast Abnormality Prognosis and Robust Characterization from Mammography Images Using Deep Transfer Learning

Mahmood

Pei

et al. 2021

Biology

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“…With the latest enhancement of machine learning and deep learning, approaches, CADx schemes have led to great improvements in the automatic diagnosis of BC in its early stages ( Ragab et al, 2021 ). CADx can help doctors and pathologists in analyzing histopathological images, thus reducing the cost of diagnosis ( Kumar et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Histo-CADx: duo cascaded fusion stages for breast cancer diagnosis from histopathological images

Attallah

Anwar

Ghanem

et al. 2021

PeerJ Computer Science

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Breast cancer (BC) is one of the most common types of cancer that affects females worldwide. It may lead to irreversible complications and even death due to late diagnosis and treatment. The pathological analysis is considered the gold standard for BC detection, but it is a challenging task. Automatic diagnosis of BC could reduce death rates, by creating a computer aided diagnosis (CADx) system capable of accurately identifying BC at an early stage and decreasing the time consumed by pathologists during examinations. This paper proposes a novel CADx system named Histo-CADx for the automatic diagnosis of BC. Most related studies were based on individual deep learning methods. Also, studies did not examine the influence of fusing features from multiple CNNs and handcrafted features. In addition, related studies did not investigate the best combination of fused features that influence the performance of the CADx. Therefore, Histo-CADx is based on two stages of fusion. The first fusion stage involves the investigation of the impact of fusing several deep learning (DL) techniques with handcrafted feature extraction methods using the auto-encoder DL method. This stage also examines and searches for a suitable set of fused features that could improve the performance of Histo-CADx. The second fusion stage constructs a multiple classifier system (MCS) for fusing outputs from three classifiers, to further improve the accuracy of the proposed Histo-CADx. The performance of Histo-CADx is evaluated using two public datasets; specifically, the BreakHis and the ICIAR 2018 datasets. The results from the analysis of both datasets verified that the two fusion stages of Histo-CADx successfully improved the accuracy of the CADx compared to CADx constructed with individual features. Furthermore, using the auto-encoder for the fusion process has reduced the computation cost of the system. Moreover, the results after the two fusion stages confirmed that Histo-CADx is reliable and has the capacity of classifying BC more accurately compared to other latest studies. Consequently, it can be used by pathologists to help them in the accurate diagnosis of BC. In addition, it can decrease the time and effort needed by medical experts during the examination.

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“…Moreover, the authors in reference [23] use a network propagation method with a deep embedded clustering (DEC) method to classify the breast tumors into four subtypes. Reference [24] employs deep learning techniques for feature extraction and classification to classify breast cancer lesions using mammograms. The system achieved high accuracy using fused deep features for two datasets compared to similar methods.…”

Section: Introductionmentioning

confidence: 99%

A Cascade Deep Forest Model for Breast Cancer Subtype Classification Using Multi-Omics Data

El-Nabawy¹,

Belal

El-Bendary

2021

Mathematics

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Automated diagnosis systems aim to reduce the cost of diagnosis while maintaining the same efficiency. Many methods have been used for breast cancer subtype classification. Some use single data source, while others integrate many data sources, the case that results in reduced computational performance as opposed to accuracy. Breast cancer data, especially biological data, is known for its imbalance, with lack of extensive amounts of histopathological images as biological data. Recent studies have shown that cascade Deep Forest ensemble model achieves a competitive classification accuracy compared with other alternatives, such as the general ensemble learning methods and the conventional deep neural networks (DNNs), especially for imbalanced training sets, through learning hyper-representations through using cascade ensemble decision trees. In this work, a cascade Deep Forest is employed to classify breast cancer subtypes, IntClust and Pam50, using multi-omics datasets and different configurations. The results obtained recorded an accuracy of 83.45% for 5 subtypes and 77.55% for 10 subtypes. The significance of this work is that it is shown that using gene expression data alone with the cascade Deep Forest classifier achieves comparable accuracy to other techniques with higher computational performance, where the time recorded is about 5 s for 10 subtypes, and 7 s for 5 subtypes.

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A framework for breast cancer classification using Multi-DCNNs

Cited by 108 publications

References 69 publications

An Automated In-Depth Feature Learning Algorithm for Breast Abnormality Prognosis and Robust Characterization from Mammography Images Using Deep Transfer Learning

An Automated In-Depth Feature Learning Algorithm for Breast Abnormality Prognosis and Robust Characterization from Mammography Images Using Deep Transfer Learning

Histo-CADx: duo cascaded fusion stages for breast cancer diagnosis from histopathological images

A Cascade Deep Forest Model for Breast Cancer Subtype Classification Using Multi-Omics Data

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