A framework based on sulcal constraints to align preterm, infant and adult human brain images acquired in vivo and post mortem

Lebenberg, Jessica; Labit, M.; Auzias, Guillaume; Mohlberg, Hartmut; Fischer, Clara; Rivière, Denis; Duchesnay, Édouard; Kabdebon, Claire; Leroy, F.; Labra, Nicole; Poupon, Fabrice; Dickscheid, Timo; Hertz‐Pannier, Lucie; Poupon, Cyril; Dehaene‐Lambertz, Ghislaine; Hüppi, Petra Susan; Amunts, Katrin; Dubois, Julia; Mangin, J.-F.

doi:10.1007/s00429-018-1735-9

Cited by 27 publications

(22 citation statements)

References 63 publications

(70 reference statements)

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“…37). Based on cortical and brain surfaces, it is possible to identify “sulcal objects” ( e : illustrations for a preterm newborn at 31w PMA, a full‐term newborn at 38w PMA, and infants at 1 and 4 months of age) which can be used to perform morphological measurements during development 48 or to register brains of different sizes 49 …”

Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

“…Some use the segmented tissue maps instead of raw T 1 w and T 2 w images, and consider both these maps and cortical surfaces in the nonlinear registration process 53 . Similarly, a two‐step landmark‐based strategy allowed to registering the brains of preterm newborns, infants, and various databases of adults 49 . The DISCO method (diffeomorphic sulcal‐based cortical registration) can be used to embed sulcal constraints in a registration framework used to initialize the DARTEL step (diffeomorphic anatomical registration using exponentiated Lie algebra; implemented in SPM software [MatLab, MathWorks, Natick, MA]) (Fig.…”

Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

“…Averaged maps over a newborns' group. The DISCO+DARTEL registration framework 49 was used to register data of 40 full‐term newborns (first dHCP release: PMA between 37 and 44 weeks). The averages of registered images and maps are presented for T 2 w images (a) , cortical ribbons (b) , DTI maps ( c,d : axial λ // and radial λ ┴ diffusivities), and NODDI maps ( e : neurite density index NDI, f : orientation dispersion index ODI).…”

Section: Diffusion Mrimentioning

confidence: 99%

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MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

Dubois

Alison

Counsell

et al. 2020

Magnetic Resonance Imaging

110

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In recent years, exploration of the developing brain has become a major focus for researchers and clinicians in an attempt to understand what allows children to acquire amazing and unique abilities, as well as the impact of early disruptions (eg, prematurity, neonatal insults) that can lead to a wide range of neurodevelopmental disorders. Noninvasive neuroimaging methods such as MRI are essential to establish links between the brain and behavioral changes in newborns and infants. In this review article, we aim to highlight recent and representative studies using the various techniques available: anatomical MRI, quantitative MRI (relaxometry, diffusion MRI), multiparametric approaches, and functional MRI. Today, protocols use 1.5 or 3T MRI scanners, and specialized methodologies have been put in place for data acquisition and processing to address the methodological challenges specific to this population, such as sensitivity to motion. MR sequences must be adapted to the brains of newborns and infants to obtain relevant good soft‐tissue contrast, given the small size of the cerebral structures and the incomplete maturation of tissues. The use of age‐specific image postprocessing tools is also essential, as signal and contrast differ from the adult brain. Appropriate methodologies then make it possible to explore multiple neurodevelopmental mechanisms in a precise way, and assess changes with age or differences between groups of subjects, particularly through large‐scale projects. Although MRI measurements only indirectly reflect the complex series of dynamic processes observed throughout development at the molecular and cellular levels, this technique can provide information on brain morphology, structural connectivity, microstructural properties of gray and white matter, and on the functional architecture. Finally, MRI measures related to clinical, behavioral, and electrophysiological markers have a key role to play from a diagnostic and prognostic perspective in the implementation of early interventions to avoid long‐term disabilities in children. Evidence Level 2 Technical Efficacy Stage 1

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Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

Section: Diffusion Mrimentioning

confidence: 99%

See 1 more Smart Citation

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

Dubois

Alison

Counsell

et al. 2020

Magnetic Resonance Imaging

110

View full text Add to dashboard Cite

show abstract

“…In many contexts, such as brain development or crossspecies comparisons, the manual identification of sulcal landmarks is vital to constrain the registration algorithm when automatic labeling is inaccurate or not feasible (Van Essen and Dierker 2007;Lebenberg et al 2018;Eichert et al 2020b). Here, we show that manual identification of sulcal landmarks is also critical for registrations in the human brain, particularly in brain regions that are highly variable and have low gyrification.…”

Section: Relationship Between Variability In Structure and Functionmentioning

confidence: 81%

Morphological and functional variability in central and subcentral motor cortex of the human brain

et al. 2020

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There is a long-established link between anatomy and function in the somatomotor system in the mammalian cerebral cortex. The morphology of the central sulcus is predictive of the location of functional activation peaks relating to movement of different effectors in individuals. By contrast, morphological variation in the subcentral region and its relationship to function is, as yet, unknown. Investigating the subcentral region is particularly important in the context of speech, since control of the larynx during human speech production is related to activity in this region. Here, we examined the relationship between morphology in the central and subcentral region and the location of functional activity during movement of the hand, lips, tongue, and larynx at the individual participant level. We provide a systematic description of the sulcal patterns of the subcentral and adjacent opercular cortex, including the inter-individual variability in sulcal morphology. We show that, in the majority of participants, the anterior subcentral sulcus is not continuous, but consists of two distinct segments. A robust relationship between morphology of the central and subcentral sulcal segments and movement of different effectors is demonstrated. Inter-individual variability of underlying anatomy might thus explain previous inconsistent findings, in particular regarding the ventral larynx area in subcentral cortex. A surface registration based on sulcal labels indicated that such anatomical information can improve the alignment of functional data for group studies.

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“…A registration based on individually drawn sulci showed an improved registration for the left ventral larynx representation, when compared to a registration based on sulcal depth and based on FreeSurfer labels, which rely on prominent and consistent landmarks, such as deep sulci. In many contexts, such as brain development or cross-species comparisons, the manual identification of sulcal landmarks is vital to constrain the registration algorithm when automatic labelling is inaccurate or infeasible (Van Essen and Dierker 2007;Lebenberg et al 2018;Eichert et al 2020b). Here we show, however, that manual identification of sulcal landmarks is also critical for registrations in the human brain, particularly in brain regions that are highly variable and have low gyrification.…”

Section: Relationship Between Variability In Structure and Functionmentioning

confidence: 99%

Morphological and functional variability in central and subcentral motor cortex of the human brain

Eichert

Watkins

Mars

et al. 2020

Preprint

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There is a long-established link between anatomy and function in the somatomotor system in the mammalian cerebral cortex. Morphology of the central sulcus predicts the location of functional activation peaks in individuals, but morphological variation in the subcentral region and its relationship to functional activation is unknown. Investigating the subcentral region is particularly important in the context of speech, since control of the larynx during human speech production activates this region. Here, we examined whether morphological variation in the central and subcentral region is related to functional activation during movement of the hand, lips, tongue, and larynx at the individual subject level. We provide a systematic description of the sulcal pattern of the subcentral and adjacent opercular cortex, including the inter-individual variability of sulcal morphology. We found a robust relationship between morphology of the central and subcentral sulcal segments and movement of different effectors. A surface registration based on sulci revealed that anatomical variability explains, in part, spatial variability in function.Significance StatementThere is a long established relationship between structure and function in the somatomotor system in the mammalian brain. Here, we show that the location of brain activations during movement involving different effectors relates to morphological landmarks in the central sulcus and the subcentral region of the cerebral cortex. We provide a systematic description of the morphological patterns of the subcentral cortical region and the inter-individual anatomical variability of sulcal segments. We discuss how structural variability can explain spatial variability in functional activations, which is a critical factor for cross-subject registrations in group studies.

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A framework based on sulcal constraints to align preterm, infant and adult human brain images acquired in vivo and post mortem

Cited by 27 publications

References 63 publications

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

Morphological and functional variability in central and subcentral motor cortex of the human brain

Morphological and functional variability in central and subcentral motor cortex of the human brain

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