2000
DOI: 10.1002/(sici)1097-0177(200005)218:1<189::aid-dvdy16>3.0.co;2-4
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A fragment of theneurogenin1 gene confers regulated expression of a reporter gene in vitro and in vivo

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Cited by 15 publications
(12 citation statements)
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References 26 publications
(61 reference statements)
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“…1, 2C,C′). This is consistent with early studies that showed this region worked only inefficiently at directing expression of a reporter to Neurog1 domains in transgenic mice (Murray et al, 2000; Nakada et al, 2004). …”
Section: Resultssupporting
confidence: 91%
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“…1, 2C,C′). This is consistent with early studies that showed this region worked only inefficiently at directing expression of a reporter to Neurog1 domains in transgenic mice (Murray et al, 2000; Nakada et al, 2004). …”
Section: Resultssupporting
confidence: 91%
“…As such, the temporal and spatial control of Neurog1 expression is complex and includes multiple discrete regulatory regions spread over more than 20 kb surrounding the coding exon. Over the past decade, work in zebrafish and mouse has identified multiple cis-regulatory sequences for Neurog1 using sufficiency assays in transgenic animals (Blader et al, 2004; Blader et al, 2003; Gowan et al, 2001; Murray et al, 2000; Nakada et al, 2004). Here, using BAC transgenic mice to test the requirement of these sequences in directing neural specific expression in vivo, we find additional complexities including an apparent redundancy in enhancer activity, new activities for a previously defined enhancer, and localization of an enhancer for ventral neural tube expression.…”
Section: Discussionmentioning
confidence: 99%
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“…We found a consensus sequence for TCF binding (van de Wetering et al, 1997) located at nucleotide (nt) positions -1167 to -1160 relative to the transcription start site of the mouse Ngn1 gene. This region within the promoter has been shown to be responsible for expression of the gene in the dorsal neocortex during neurogenesis (Murray et al, 2000). To determine whether this TCF binding element is functional, we compared the activities of the Ngn1 gene promoter (nt -2670 to +74) containing either an intact or mutated version of this DNA sequence (Fig.…”
Section: Direct Regulation Of the Ngn1 Promoter By The β-Catenin/tcf mentioning
confidence: 99%
“…These residues are indicated on the corresponding model (right part of figure). around 140 nucleotides upstream of the start of the transcription site of neurogenin1, a transcription factor essential for neuronal differentiation and subtype specification during embryogenesis (33,34). Interestingly, when NZF3, a member of the same protein family to which MyT1 belongs, and Neurog1 are co-expressed in cells, the rate of neuronal differentiation is significantly increased, suggesting that these proteins act in concert to stimulate these processes (35).…”
Section: Differences In the Dna Binding Mode Between Myt1mentioning
confidence: 99%