A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish
Ugo Coppola,
Jennifer Kenney,
Joshua S. Waxman
Abstract:Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte (AC) differentiation. However, little is known about the mechanisms directing Nr2f expression in ACs. Here, we identified a conserved enhancer 3′ to the nr2f1a locus, which we call 3’reg1-nr2f1a (3′reg1), that can promote Nr2f1a expression in ACs. Sequence analysis of the enhancer identified putative Lef/Tcf and Foxf TF binding sites. Mutation of the Lef/Tcf sites within the 3′reg1 reporter, knockdown of Tcf7l1a, and m… Show more
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