A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates

Viazis, N.; Argyriou, Konstantinos; Kotzampassi, Katerina; Christodoulou, Dimitrios; Apostolopoulos, Periklis; Georgopoulos, Sotirios D.; Liatsos, Christos; Γιουλεμέ, Όλγα; Koustenis, K; Veretanos, C; Stogiannou, Dimitris; Moutzoukis, M; Poutakidis, Charalambos; Mylonas, Ioannis; Tseti, Ioulia; Mantzaris, Gerassimos J.

doi:10.3390/nu14030632

Cited by 33 publications

(20 citation statements)

References 40 publications

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“…Generally speaking, Lactobacillus strains are capable of inducing proinflammatory cytokines such as IL-12 and IFN-γ in addition to anti-inflammatory cytokines such as IL-10 [49], whereas Bifidobacterium strains are generally better inducers of IL-10 than Lactobacillus strains [44,50]. This is why the combination of species is preferable, as in our study, where the well-tested, in previous RCTs of our study group [26,51,52], LactoLevure ® regime was used.…”

Section: Discussionmentioning

confidence: 84%

A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients

et al. 2022

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Investigations that focused on the protective role of probiotics against Surgical Site Infections (SSI) in multiple-trauma (MT) patients are generally few, probably due to the complexity of the concept of trauma. We aimed to assess the efficacy of a four-probiotic regime to reduce the incidence of SSI in MT patients, with a brain injury included. MT patients, being intubated and expected to require mechanical ventilation for >10 days, were randomly allocated into placebo (n = 50) or probiotic treatment (n = 53) comprising Lactobacillus acidophilus LA-5 (1.75 × 109 cfu), Lactiplantibacillus plantarum UBLP-40 (0.5 × 109 cfu), Bifidobacterium animalis subsp. lactis BB-12 (1.75 × 109 cfu), and Saccharomycesboulardii Unique-28 (1.5 × 109 cfu) in sachets. All patients received two sachets of placebo or probiotics twice/day for 15 days and were followed-up for 30 days. The operations were classified as neurosurgical, thoracostomies, laparotomies, orthopedics, and others; then, the SSI and the isolated pathogen were registered. A total of 23 (46.0%) and 13 (24.5%) infectious insults in 89 (50 placebo patients) and 88 (53 probiotics-treated) operations (p = 0.022) were recorded, the majority of them relating to osteosynthesis—17 and 8, respectively. The most commonly identified pathogens were Staphylococcus aureus and Acinetobacter baumannii. Our results support published evidence that the prophylactic administration of probiotics in MT patients exerts a positive effect on the incidence of SSI.

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Section: Discussionmentioning

confidence: 84%

A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients

et al. 2022

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“…Yuan et al found that after probiotics supplemented eradication treatment, pathogenic bacteria like Fusobacterium and Campylobacter decreased. The microbial diversity was closer to H. pylori-negative subjects than in the other quadruple therapy group [ 18 ].…”

Section: Reviewmentioning

confidence: 99%

Role of Probiotics in the Management of Helicobacter pylori

Mestre¹,

Narayanan²,

Rivas³

et al. 2022

Cureus

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The global prevalence of Helicobacter pylori (H. pylori) is estimated to be around 4.4 billion, with the majority of individuals affected in developing countries. Chronic infection of the gram-negative bacterium results in several gastrointestinal pathologies such as chronic gastritis, peptic ulcer, and cancer. Probiotics compete directly with H. pylori and help restore the gut microbial environment; these living microorganisms are comparatively more effective than the standard triple antibiotic regimen in the management of symptoms related to the pathogenic bacteria. The need for alternative therapy is better explained by the increasing rate of antibiotic resistance and the lowering of patient compliance to the standard treatment. Adjuvant administration of probiotics to H. pylori eradication therapy is associated with a higher H. pylori eradication rate, decreased diarrhea-related treatment, less common self-reported side effects, and higher treatment compliance. Therefore, with the ongoing and future resistance to antibiotics, this systematic review aims to investigate the use and efficacy of probiotics when used alone or in conjunction with the current guideline treatment.A literature search was conducted using Pubmed, MEDLINE, and Cochrane for peer-reviewed articles published between January 1, 2016 and April 2022. MeSH terms used were: "H. pylori," "H. pylori and probiotics," "Probiotics," "H. pylori treatment," "Mechanism of Action" with subheadings as "clinical manifestations," "treatment," and "diagnosis." All literature reviews, original papers, and case reports were included. This search strategy aimed to find literature that could describe the transmission and mechanism of action of H. pylori, the current treatment guidelines, and the efficacy of probiotics in eradicating H. pylori.

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“…Bicarbonate is the precursor of CO 2 that is incorporated into breath. After an overnight fast, all patients swallowed a capsule containing 14 C-urea with 20 mL of water. Fifteen minutes after capsule intake, each patient blew into a dry cartridge until the breath-card indicator turned from orange to yellow.…”

Section: Evaluation Parametersmentioning

confidence: 99%

“…Fifteen minutes after capsule intake, each patient blew into a dry cartridge until the breath-card indicator turned from orange to yellow. 14 CO 2 collected by the breath card was measured with the H. pylori analyzer, and disintegrations per minute (DPM) > 100 were judged as positive for H. pylori infection.…”

Section: Evaluation Parametersmentioning

confidence: 99%

“…Clinical trials have suggested that a combination of Lactobacillus spp. (e.g., L. acidophilus [14,15], L. reuteri [16], L. rhamnosus [17,18], L. plantarum [14], L. bulgaricus [18], L. casei [18], and L. sporogenes [19]) and conventional antibiotic treatment has positive effects on both the eradication rate of H. pylori and/or the incidence of overall side effects. A recent meta-analysis (40 articles, 5792 patients) about the efficacy of probiotic-supplemented therapy on the eradication of H. pylori and incidence of therapy-associated side effects showed that probiotic supplementation improved the eradication rate by approximately 10% relative to the control group, and the side effects of antibiotic treatment (e.g., diarrhea, vomiting and nausea, constipation, epigastric pain, and taste disturbance) also decreased significantly with probiotic supplementation [20].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Potential Protective Effects of Lactobacillus Strains against Helicobacter pylori Infection: A Randomized, Double-Blinded, Placebo-Controlled Trial

Wang

Zhai

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. The beneficial effects of probiotic supplementation standard antibiotic therapies for Helicobacter pylori infection have been verified, but the ability of probiotic monotherapy to eradicate H. pylori remains unclear. Aim. To evaluate the accuracy and efficacy of specific Lactobacillus strains against H. pylori infection. Methods. Seventy-eight patients with H. pylori infection were treated with strain L. crispatus G14-5M (L. crispatus CCFM1118) or L. helveticus M2-09-R02-S146 (L. helveticus CCFM1121) or L. plantarum CCFM8610 at a dose of 2 g twice daily for one month. 14C-urea breath test, the gastrointestinal symptom rating scale, serum pepsinogen concentrations, and serum cytokine concentrations of patients were measured at baseline and end-of-trial to analyze the effect of the Lactobacillus strains in eradicating H. pylori infection and reducing gastrointestinal discomfort in patients. In addition, the composition and abundance of the intestinal microbiota of patients were also measured at end-of-trial. Results. The 14C-urea breath test value of the three Lactobacillus treatment groups had decreased significantly, and the eradication rate of H. pylori had increased by the end of the trial. In particular, the eradication rate in the G14-5M treatment group was significantly higher than the placebo group (70.59% vs. 15.38%, P = 0.0039 ), indicating that one-month administration of the G14-5M regimen was sufficient to eradicate H. pylori infection. The ingestion of Lactobacillus strains also ameliorated the gastrointestinal symptom rating scale scores, and the serum interleukin-8 concentrations of H. pylori-infected patients appeared to modulate the gut microbiota of patients. However, none of the Lactobacillus strains had a significant effect on general blood physiological characteristics, serum tumor necrosis factor α concentrations, or serum pepsinogen concentrations in the patients. Conclusion. Three Lactobacillus strains significantly alleviate the gastrointestinal discomfort and the gastric inflammatory response of H. pylori-infected patients. The activity of probiotics in eradicating H. pyloriinfection may be species/strain specific.

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A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates

Cited by 33 publications

References 40 publications

A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients

A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients

Role of Probiotics in the Management of Helicobacter pylori

Evaluation of the Potential Protective Effects of Lactobacillus Strains against Helicobacter pylori Infection: A Randomized, Double-Blinded, Placebo-Controlled Trial

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