A Fotobiomodulação No Processo Cicatricial Da Pele - Revisão Da Literatura / Photobiomodulation in Wound Healing Process - Literature Review

Abstract

respostas anti-inflamatória e analgésica, sendo outra característica o potencial bioestimulante que ocorre nas células, proporcionando uma cicatrização mais rápida. Embora a aplicação do LBI seja de simples execução, há necessidade de avaliar a especificidade dos parâmetros, uma vez que, durante o protocolo de tratamento, cada um deles é essencial para alcançar o efeito desejado. Cromóforos são moléculas com afinidade pela luz, encontram-se nas mitocôndrias que, ao entrar em ontato com o LBI, geram aumento do ATP levando à ativação de fatores de transcrição, acarretando a estimulação de genes relacionados à proliferação celular, migração e produção de citocinas e fatores de crescimento, favorecendo o processo cicatricial da pele.

Photobiomodulation Therapy to Treat Snakebites Caused by Bothrops atrox

“… 26 This action results from the modulation of the immune system, decreases the production and release of inflammation mediators, increases the production of mitochondrial adenosine triphosphate, thus decreasing cellular oxidative stress and apoptosis, and stimulates neovascularization. 53 , 54 , 55 , 56 The efficacy results of this study corroborated the efficacy observed in previous preclinical studies in animals that were experimentally subjected to Bothrops venom. 28 , 40 , 57 …”

“…There is evidence that LLLT improves blood flow, which increases the reabsorption of edema and the clearance of catabolites derived from the inflammatory process, as well as providing an efficient supply of nutritional and defensive elements to the injured region . This action results from the modulation of the immune system, decreases the production and release of inflammation mediators, increases the production of mitochondrial adenosine triphosphate, thus decreasing cellular oxidative stress and apoptosis, and stimulates neovascularization . The efficacy results of this study corroborated the efficacy observed in previous preclinical studies in animals that were experimentally subjected to Bothrops venom …”

Photobiomodulation effects on synovial morphology, iNOS gene, and protein expression in a model of acute inflammation

“…Low-level laser PBM is emerging as an alternative to the use of drugs. PBM with low-level laser has photochemical, photophysical, and photobiological mechanisms, particularly via cytochrome C oxidase, a terminal enzyme in the mitochondrial electron transport chain that causes changes in the biological system by increasing adenosine triphosphate (ATP) production 17 , 18 . In our study, it is believed that mitochondrial pathways are stimulated after PBM, which is related to the increase in iNOS expression in synovial cells.…”

“…As a result of the increase in ATP, the cells undergo biostimulation, promoting possible therapeutic effects such as morphodifferentiation and cell proliferation, tissue neoformation, increased local microcirculation through angiogenesis, anti-inflammatory and analgesic potential 18 .…”

Physicochemical Properties of a Bioactive Polysaccharide Film from Cassia grandis with Immobilized Collagenase from Streptomyces parvulus (DPUA/1573)

“…The inflammatory phase aims to remove devitalized tissues, the proliferative phase focuses on tissue formation through fibroblast proliferation and collagen production, and the maturation phase involves collagen type replacement, lasting from 6 months to 2 years. Complications can affect scar characteristics [3][4][5][6][7]. Recognizing the vital importance of biodiversity, the international community has established the Sustainable Development Goals (SDGs), including SDG 15, which aims to protect, restore, and promote the sustainable use of terrestrial ecosystems [8,9].…”